503 Tumor infiltrating lymphocytes in soft tissue sarcomas upregulate the exhaustion marker TIGIT and are reinvigorated by IL-15 stimulation and TIGIT blockade

Sean Judge; Morgan Darrow; Steven Thorpe; Alicia Gingrich; Edmond O’Donnell; Alyssa Bellini; Ian Sturgill; Logan Vick; Cordelia Dunai; Kevin Stoffel; Yue Lyu; Shuai Chen; May Cho; Robert Rebhun; Arta Monjazeb; William Murphy; Robert Canter

doi:10.1136/jitc-2020-SITC2020.0503

Article info

Regular and young investigator award abstracts

Immune cell biology

503 Tumor infiltrating lymphocytes in soft tissue sarcomas upregulate the exhaustion marker TIGIT and are reinvigorated by IL-15 stimulation and TIGIT blockade

Authors

Sean Judge University of California, Davis, Sacramento, CA, USA PubMed articles Google scholar articles
Morgan Darrow University of California, Davis, Sacramento, CA, USA PubMed articles Google scholar articles
Steven Thorpe University of California, Davis, Sacramento, CA, USA PubMed articles Google scholar articles
Alicia Gingrich University of California, Davis, Sacramento, CA, USA PubMed articles Google scholar articles
Edmond O’Donnell University of California, Davis, Sacramento, CA, USA PubMed articles Google scholar articles
Alyssa Bellini University of California, Davis, Sacramento, CA, USA PubMed articles Google scholar articles
Ian Sturgill University of California, Davis, Sacramento, CA, USA PubMed articles Google scholar articles
Logan Vick University of California, Davis, Sacramento, CA, USA PubMed articles Google scholar articles
Cordelia Dunai University of California, Davis, Sacramento, CA, USA PubMed articles Google scholar articles
Kevin Stoffel University of California, Davis, Sacramento, CA, USA PubMed articles Google scholar articles
Yue Lyu University of California, Davis, Sacramento, CA, USA PubMed articles Google scholar articles
Shuai Chen University of California, Davis, Sacramento, CA, USA PubMed articles Google scholar articles
May Cho University of California, Davis, Sacramento, CA, USA PubMed articles Google scholar articles
Robert Rebhun University of California, Davis, Sacramento, CA, USA PubMed articles Google scholar articles
Arta Monjazeb University of California, Davis, Sacramento, CA, USA PubMed articles Google scholar articles
William Murphy University of California, Davis, Sacramento, CA, USA PubMed articles Google scholar articles
Robert Canter University of California, Davis, Sacramento, CA, USA PubMed articles Google scholar articles

Citation

Judge S, Darrow M, Thorpe S, et al

503 Tumor infiltrating lymphocytes in soft tissue sarcomas upregulate the exhaustion marker TIGIT and are reinvigorated by IL-15 stimulation and TIGIT blockade

Journal for ImmunoTherapy of Cancer 2020;8:doi: 10.1136/jitc-2020-SITC2020.0503

Publication history

First published December 10, 2020.

Online issue publication

December 12, 2020

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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