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596 Armed myxoma virus demonstrates therapeutic activity in xenograft models
  1. Lino Torres-Dominguez,
  2. Lina Franco,
  3. Mario Abrantes,
  4. Benjamin Walker,
  5. Zachary Tacner,
  6. Cassandra Kien,
  7. Natalie Elliott,
  8. Anna Waters,
  9. Grant McFadden,
  10. Steven Potts and
  11. Leslie Sharp
  1. OncMyx Therapeutics, Phoenix, AZ, USA


Background Oncolytic Viruses (OV) selectively replicate in and lyse tumor cells and provide stimulation to the immune system. This represents a promising therapeutic option for cancer patients that do not respond well to treatment with immune checkpoint inhibitors. Myxoma virus (MYXV) is a member of the Pox family of double stranded DNA viruses. The natural host of MYXV is a subset of rabbits and hares, but MYXV is able to infect cancer cell lines of humans and other species. The genome of MYXV is relatively large and is amenable to engineering for expression of transgenic proteins making it an excellent oncolytic virus for introduction of immunomodulatory proteins.

Methods The current work describes the in vitro oncolytic activity and transgene production capability in human cancer cell lines, and in vivo activity of armed myxoma viruses in xenograft human cancer models.

Results Armed Myxoma viruses demonstrate transgene production and oncolytic activity in multiple human cancer cell lines in vitro and in vivo

Conclusions Armed Myxoma viruses present a novel oncolytic viral therapy with ability to modulate immune responses in human cancer models

Ethics Approval This study was approved by OncoMyx Therapeutics and the TD2 IACUC

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See:

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