860 Targeting immunosuppressive macrophages overcomes PARP-inhibitor resistance in BRCA1-associated triple-negative breast cancer

Anita Mehta; Emily Cheney; Christina Hartl; Constantia Pantelidou; Madison Oliwa; Jessica Castrillon; Jia-Ren Lin; Katie Hurst; Mateus de Oliveira Taveira; Nathan Johnson; William Oldham; Marian Kalocsay; Matthew Berberich; Sarah Boswell; Aditi Kothari; Shawn Johnson; Deborah Dillon; Mikel Lipschitz; Scott Rodig; Sandro Santagata; Judy Garber; Nadine Tung; José Yélamos; Jessica Thaxton; Elizabeth Mittendorf; Peter Sorger; Geoffrey Shapiro; Jennifer Guerriero

doi:10.1136/jitc-2020-SITC2020.0860

Article info

Late-breaking abstracts

Novel single-agent immunotherapies

860 Targeting immunosuppressive macrophages overcomes PARP-inhibitor resistance in BRCA1-associated triple-negative breast cancer

Authors

Anita Mehta Dana Farber Cancer Institute, Boston, MA, USA PubMed articles Google scholar articles
Emily Cheney Dana Farber Cancer Institute, Boston, MA, USA PubMed articles Google scholar articles
Christina Hartl Dana Farber Cancer Institute, Boston, MA, USA PubMed articles Google scholar articles
Constantia Pantelidou Dana Farber Cancer Institute, Boston, MA, USA PubMed articles Google scholar articles
Madison Oliwa Dana-Farber Cancer Institute and Harvard, Boston, USA PubMed articles Google scholar articles
Jessica Castrillon Dana Farber Cancer Institute, Boston, MA, USA PubMed articles Google scholar articles
Jia-Ren Lin Harvard Medical School, Boston, MA, USA PubMed articles Google scholar articles
Katie Hurst Medical University of South Carolina, Charleston, SC, USA PubMed articles Google scholar articles
Mateus de Oliveira Taveira A.C. Camargo Cancer Center, São Paulo, Brazil PubMed articles Google scholar articles
Nathan Johnson Harvard Medical School, Boston, MA, USA PubMed articles Google scholar articles
William Oldham Brigham and Women’s Hospital and Harvard, Boston, MA, USA PubMed articles Google scholar articles
Marian Kalocsay Harvard Medical School, Boston, MA, USA PubMed articles Google scholar articles
Matthew Berberich Harvard Medical School, Boston, MA, USA PubMed articles Google scholar articles
Sarah Boswell Harvard Medical School, Boston, MA, USA PubMed articles Google scholar articles
Aditi Kothari Dana Farber Cancer Institute, Boston, MA, USA PubMed articles Google scholar articles
Shawn Johnson Dana Farber Cancer Institute, Boston, MA, USA PubMed articles Google scholar articles
Deborah Dillon Brigham and Women’s Hospital and Harvard, Boston, MA, USA PubMed articles Google scholar articles
Mikel Lipschitz Brigham and Women’s Hospital and Harvard, Boston, MA, USA PubMed articles Google scholar articles
Scott Rodig Brigham and Women’s Hospital and Harvard, Boston, MA, USA PubMed articles Google scholar articles
Sandro Santagata Brigham and Women’s Hospital and Harvard, Boston, MA, USA PubMed articles Google scholar articles
Judy Garber Dana Farber Cancer Institute, Boston, MA, USA PubMed articles Google scholar articles
Nadine Tung Beth Israel Deaconess Medical Center, Boston, MA, USA PubMed articles Google scholar articles
José Yélamos Medical Research Institute, Barcelona, Spain PubMed articles Google scholar articles
Jessica Thaxton Medical University of South Carolina, Charleston, SC, USA PubMed articles Google scholar articles
Elizabeth Mittendorf Dana Farber Cancer Institute, Boston, MA, USA PubMed articles Google scholar articles
Peter Sorger Harvard Medical School, Boston, MA, USA PubMed articles Google scholar articles
Geoffrey Shapiro Dana Farber Cancer Institute, Boston, MA, USA PubMed articles Google scholar articles
Jennifer Guerriero Dana Farber Cancer Institute, Boston, MA, USA PubMed articles Google scholar articles

Citation

Mehta A, Cheney E, Hartl C, et al

860 Targeting immunosuppressive macrophages overcomes PARP-inhibitor resistance in BRCA1-associated triple-negative breast cancer

Journal for ImmunoTherapy of Cancer 2020;8:doi: 10.1136/jitc-2020-SITC2020.0860

Publication history

First published December 10, 2020.

Online issue publication

December 12, 2020

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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