Journal for ImmunoTherapy of Cancer: 9 (1)

Basic tumor immunology

Original research: CD8+CD103+ tissue-resident memory T cells convey reduced protective immunity in cutaneous squamous cell carcinoma (21 January, 2021)
Chester Lai, George Coltart, Andrew Shapanis, Conor Healy, Ahmad Alabdulkareem, Sara Selvendran, Jeffrey Theaker, Matthew Sommerlad, Matthew Rose-Zerilli, Aymen Al-Shamkhani, Eugene Healy
Original research: Anticancer immunity induced by a synthetic tumor-targeted CD137 agonist (26 January, 2021)
Punit Upadhyaya, Johanna Lahdenranta, Kristen Hurov, Sailaja Battula, Rachel Dods, Eric Haines, Marianna Kleyman, Julia Kristensson, Jessica Kublin, Rachid Lani, Jun Ma, Gemma Mudd, Elizabeth Repash, Katerine Van Rietschoten, Tom Stephen, Fanglei You, Helen Harrison, Liuhong Chen, Kevin McDonnell, Philip Brandish, Nicholas Keen
Original research: Inability of granule polarization by NK cells defines tumor resistance and can be overcome by CAR or ADCC mediated targeting (19 January, 2021)
Jiri Eitler, Natalie Wotschel, Nicole Miller, Laurent Boissel, Hans G Klingemann, Winfried Wels, Torsten Tonn
Estrogen receptor beta signaling in CD8⁺ T cells boosts T cell receptor activation and antitumor immunity through a phosphotyrosine switch
(18 January, 2021)
Bin Yuan, Curtis A Clark, Bogang Wu, Jing Yang, Justin M Drerup, Tianbao Li, Victor X Jin, Yanfen Hu, Tyler J Curiel, Rong Li
Original research: Blocking IL-17A enhances tumor response to anti-PD-1 immunotherapy in microsatellite stable colorectal cancer (18 January, 2021)
Chao Liu, Ruiqi Liu, Bojun Wang, Jie Lian, Yang Yao, Haoxiu Sun, Chunhui Zhang, Lin Fang, Xin Guan, Jiaqi Shi, Shuling Han, Fei Zhan, Shengnan Luo, Yuanfei Yao, Tongsen Zheng, Yanqiao Zhang
Original research:
Identification of neuroblastoma cell lines with uncommon TAZ⁺/mesenchymal stromal cell phenotype with strong suppressive activity on natural killer cells
(15 January, 2021)
Claudia Canzonetta, Andrea Pelosi, Sabina Di Matteo, Irene Veneziani, Nicola Tumino, Paola Vacca, Enrico Munari, Marco Pezzullo, Charles Theuer, Rita De Vito, Vito Pistoia, Luigi Tomao, Franco Locatelli, Lorenzo Moretta, Ignazio Caruana, Bruno Azzarone
Original research: Therapy of lymphoma by immune checkpoint inhibitors: the role of T cells, NK cells and cytokine-induced tumor senescence (13 January, 2021)
Fatima Ahmetlic, Josia Fauser, Tanja Riedel, Vera Bauer, Carolin Flessner, Nadine Hömberg, Roman Hennel, Ellen Brenner, Kirsten Lauber, Martin Röcken, Ralph Mocikat
Original research: Differences in TCR repertoire and T cell activation underlie the divergent outcomes of antitumor immune responses in tumor-eradicating versus tumor-progressing hosts (7 January, 2021)
Rachel A Woolaver, Xiaoguang Wang, Alexandra L Krinsky, Brittany C Waschke, Samantha M Y Chen, Vince Popolizio, Andrew G Nicklawsky, Dexiang Gao, Zhangguo Chen, Antonio Jimeno, Xiao-Jing Wang, Jing Hong Wang
Original research: Enhanced antitumor immunity by a novel small molecule HPK1 inhibitor (6 January, 2021)
Dan You, Stephen Hillerman, Gregory Locke, Charu Chaudhry, Caitlyn Stromko, Anwar Murtaza, Yi Fan, Jennifer Koenitzer, Yali Chen, Stephanie Briceno, Rajarshi Bhadra, Elizabeth Duperret, Johnni Gullo-Brown, Chan Gao, Dandan Zhao, John Feder, Joshua Curtin, Andrew P Degnan, Godwin Kumi, Mark Wittman, Benjamin M Johnson, Karen E Parrish, Giridharan Gokulrangan, John Morrison, Michael Quigley, John T Hunt, Luisa Salter-Cid, Emma Lees, Miguel A Sanjuan, Jinqi Liu
Original research: Skin immunization for effective treatment of multifocal melanoma refractory to PD1 blockade and Braf inhibitors (6 January, 2021)
Xingxing Hao, Louis D Falo III, Guo Chen, Jiying Zhang, Cara D Carey, Walter J Storkus, Louis D Falo Jr, Zhaoyang You

Case report

Tisagenlecleucel infusion in patients with relapsed/refractory ALL and concurrent serious infection (20 January, 2021)
Erin M Hall, Dwight E Yin, Rakesh K Goyal, Atif A Ahmed, Grace S Mitchell, Shawn D St. Peter, Terrie G Flatt, Ibrahim A Ahmed, Weijie Li, Richard J Hendrickson, Keith J August, G Doug Myers
Use of plasma ctDNA as a potential biomarker for longitudinal monitoring of a patient with metastatic high-risk upper tract urothelial carcinoma receiving pembrolizumab and personalized neoepitope-derived multipeptide vaccinations: a case report (11 January, 2021)
Carolin Blumendeller, Julius Boehme, Maximilian Frick, Martin Schulze, Antje Rinckleb, Christina Kyzirakos, Simone Kayser, Maria Kopp, Sabine Kelkenberg, Natalia Pieper, Oliver Bartsch, Dirk Hadaschick, Florian Battke, Arnulf Stenzl, Saskia Biskup

Clinical/translational cancer immunotherapy

Original research: Real-world experience with elective discontinuation of PD-1 inhibitors at 1 year in patients with metastatic melanoma (26 January, 2021)
Rebecca Pokorny, Jordan P McPherson, Benjamin Haaland, Kenneth F Grossmann, Carolyn Luckett, Benjamin Newell Voorhies, Daniel S Sageser, Jocelyn Wallentine, Zachary Tolman, Siwen Hu-Lieskovan, Umang Swami
Original research: MUC1-C integrates activation of the IFN-γ pathway with suppression of the tumor immune microenvironment in triple-negative breast cancer (25 January, 2021)
Nami Yamashita, Mark Long, Atsushi Fushimi, Masaaki Yamamoto, Tsuyoshi Hata, Masayuki Hagiwara, Atrayee Bhattacharya, Qiang Hu, Kwok-Kin Wong, Song Liu, Donald Kufe
Original research: Targeting PARP-1 with metronomic therapy modulates MDSC suppressive function and enhances anti-PD-1 immunotherapy in colon cancer (25 January, 2021)
Mohamed A Ghonim, Salome V Ibba, Abdelmetalab F Tarhuni, Youssef Errami, Hanh H Luu, Matthew J Dean, Ali H El-Bahrawy, Dorota Wyczechowska, Ilyes A Benslimane, Luis Del Valle, Amir A Al-Khami, Augusto C Ochoa, A Hamid Boulares
Original research:
Preclinical PET imaging with the novel human antibody ⁸⁹Zr-DFO-REGN3504 sensitively detects PD-L1 expression in tumors and normal tissues
(22 January, 2021)
Marcus P Kelly, Sosina Makonnen, Carlos Hickey, T Cody Arnold, Jason T Giurleo, Richard Tavaré, Makenzie Danton, Christian Granados, Ishita Chatterjee, Drew Dudgeon, Marc W Retter, Dangshe Ma, William C Olson, Gavin Thurston, Jessica R Kirshner
Original research: In situ immunogenic clearance induced by a combination of photodynamic therapy and rho-kinase inhibition sensitizes immune checkpoint blockade response to elicit systemic antitumor immunity against intraocular melanoma and its metastasis (21 January, 2021)
Seohyun Kim, Seong A Kim, Gi-Hoon Nam, Yeonsun Hong, Gi Beom Kim, Yoonjeong Choi, Seokyoung Lee, Yuri Cho, Minsu Kwon, Cherlhyun Jeong, Sehoon Kim, In-San Kim
Original research: Trial to evaluate the immunogenicity and safety of a melanoma helper peptide vaccine plus incomplete Freund’s adjuvant, cyclophosphamide, and polyICLC (Mel63) (21 January, 2021)
Craig L Slingluff, Jr., Gina R Petroni, Kimberly A Chianese-Bullock, Nolan A Wages, Walter C Olson, Kelly T Smith, Kathleen Haden, Lynn T Dengel, Anna Dickinson, Caroline Reed, Elizabeth M Gaughan, William W Grosh, Varinder Kaur, Nikole Varhegyi, Mark Smolkin, Nadejda V Galeassi, Donna Deacon, Emily H Hall
Original research: Clinical impact of COVID-19 on patients with cancer treated with immune checkpoint inhibition (19 January, 2021)
Aljosja Rogiers, Ines Pires da Silva, Chiara Tentori, Carlo Alberto Tondini, Joseph M Grimes, Megan H Trager, Sharon Nahm, Leyre Zubiri, Michael Manos, Peter Bowling, Arielle Elkrief, Neha Papneja, Maria Grazia Vitale, April A N Rose, Jessica S W Borgers, Severine Roy, Joanna Mangana, Thiago Pimentel Muniz, Tim Cooksley, Jeremy Lupu, Alon Vaisman, Samuel D Saibil, Marcus O Butler, Alexander M Menzies, Matteo S Carlino, Michael Erdmann, Carola Berking, Lisa Zimmer, Dirk Schadendorf, Laura Pala, Paola Queirolo, Christian Posch, Axel Hauschild, Reinhard Dummer, John Haanen, Christian U Blank, Caroline Robert, Ryan J Sullivan, Paolo Antonio Ascierto, Wilson H Miller Jr, F Stephen Hodi, Karijn P M Suijkerbuijk, Kerry L Reynolds, Osama E Rahma, Paul C Lorigan, Richard D Carvajal, Serigne Lo, Mario Mandala, Georgina V Long
Original research: Fecal calprotectin concentration to assess endoscopic and histologic remission in patients with cancer with immune-mediated diarrhea and colitis (12 January, 2021)
Fangwen Zou, Xuemei Wang, Isabella C Glitza Oliva, Jennifer L McQuade, Jennifer Wang, Hao Chi Zhang, John A Thompson, Anusha S Thomas, Yinghong Wang
Original research: Incidence of thromboembolism in patients with melanoma on immune checkpoint inhibitor therapy and its adverse association with survival (12 January, 2021)
Tamara A Sussman, Hong Li, Brian Hobbs, Pauline Funchain, Keith R McCrae, Alok A Khorana
Original research: Steroid-refractory PD-(L)1 pneumonitis: incidence, clinical features, treatment, and outcomes (7 January, 2021)
Aanika Balaji, Melinda Hsu, Cheng Ting Lin, Josephine Feliciano, Kristen Marrone, Julie R Brahmer, Patrick M Forde, Christine Hann, Lei Zheng, Valerie Lee, Peter B Illei, Sonye K Danoff, Karthik Suresh, Jarushka Naidoo

Commentary

Letter to the editor: Checking the pulse of adoptive cell therapy for solid tumors. Thoughts from the abstracts submitted to the 35th Annual Meeting of the Society for the Immunotherapy of Cancer (SITC 2020) (8 January, 2021)
Martina Markovska, Francesco Marincola

Immune cell therapies and immune cell engineering

Original research: Metastasis-associated macrophages constrain antitumor capability of natural killer cells in the metastatic site at least partially by membrane bound transforming growth factor β (20 January, 2021)
Demi Brownlie, Dahlia Doughty-Shenton, Daniel YH Soong, Colin Nixon, Neil O Carragher, Leo M Carlin, Takanori Kitamura
Expanded human NK cells from lung cancer patients sensitize patients’ PDL1−negative tumors to PD1-blockade therapy (21 January, 2021)
Sophie M Poznanski, Tyrah M Ritchie, Isabella Y Fan, Abdullah El-Sayes, Ana L Portillo, Ronny Ben-Avi, Eduardo A Rojas, Marianne V Chew, Yaron Shargall, Ali A Ashkar
Deletion of Cbl-b inhibits CD8⁺ T-cell exhaustion and promotes CAR T-cell function
(18 January, 2021)
Jitendra Kumar, Ritesh Kumar, Amir Kumar Singh, Elviche L Tsakem, Mahesh Kathania, Matthew J Riese, Arianne L Theiss, Marco L Davila, K Venuprasad
Original research: Blockade of AIM2 inflammasome or α1-AR ameliorates IL-1β release and macrophage-mediated immunosuppression induced by CAR-T treatment (7 January, 2021)
Dan Liu, Xiyue Xu, Yulian Dai, Xuan Zhao, Shunshun Bao, Wen Ma, Li Zha, Shuci Liu, Yuchen Liu, Junnian Zheng, Ming Shi
Original research: Skin dendritic cells in melanoma are key for successful checkpoint blockade therapy (6 January, 2021)
Anastasia Prokopi, Christoph H Tripp, Bart Tummers, Florian Hornsteiner, Sarah Spoeck, Jeremy Chase Crawford, Derek R Clements, Mirjana Efremova, Katharina Hutter, Lydia Bellmann, Giuseppe Cappellano, Bruno L Cadilha, Sebastian Kobold, Louis Boon, Daniela Ortner, Zlatko Trajanoski, Suzie Chen, Tanja D de Gruijl, Juliana Idoyaga, Douglas R Green, Patrizia Stoitzner

Immunotherapy biomarkers

Original research: Biologic subtypes of melanoma predict survival benefit of combination anti-PD1+anti-CTLA4 immune checkpoint inhibitors versus anti-PD1 monotherapy (22 January, 2021)
April A N Rose, Susan M Armstrong, David Hogg, Marcus O Butler, Samuel D Saibil, Diana P Arteaga, Thiago Pimentel Muniz, Deirdre Kelly, Danny Ghazarian, Ian King, Zaid Saeed Kamil, Kendra Ross, Anna Spreafico
Original research: CXCL13 shapes immunoactive tumor microenvironment and enhances the efficacy of PD-1 checkpoint blockade in high-grade serous ovarian cancer (15 January, 2021)
Moran Yang, Jiaqi Lu, Guodong Zhang, Yiying Wang, Mengdi He, Qing Xu, Congjian Xu, Haiou Liu
Original research: Transcriptional analysis of multiple ovarian cancer cohorts reveals prognostic and immunomodulatory consequences of ERV expression (12 January, 2021)
Marina Natoli, John Gallon, Haonan Lu, Ala Amgheib, David J Pinato, Francesco A Mauri, Teresa Marafioti, Ayse U Akarca, Ines Ullmo, Jacey Ip, Eric O Aboagye, Robert Brown, Anastasios Karadimitris, Sadaf Ghaem-Maghami

Oncolytic and local immunotherapy

Original research: IL-21 arming potentiates the anti-tumor activity of an oncolytic vaccinia virus in monotherapy and combination therapy (27 January, 2021)
Tianyue Chen, Xiangqing Ding, Qibin Liao, Nan Gao, Ye Chen, Chen Zhao, Xiaoyan Zhang, Jianqing Xu
Original research: A systemically deliverable Vaccinia virus with increased capacity for intertumoral and intratumoral spread effectively treats pancreatic cancer (26 January, 2021)
Giulia Marelli, Louisa S Chard Dunmall, Ming Yuan, Carmela Di Gioia, Jinxin Miao, Zhenguo Cheng, Zhongxian Zhang, Peng Liu, Jahangir Ahmed, Rathi Gangeswaran, Nicholas Lemoine, Yaohe Wang
Original research: Immunologically programming the tumor microenvironment induces the pattern recognition receptor NLRC4-dependent antitumor immunity (19 January, 2021)
Xiaofei Yu, Wenjie Liu, Shixian Chen, Xueqian Cheng, Patrick A Paez, Tuanwei Sun, Fang Yuan, Chunyan Wei, Joseph W Landry, Andrew S Poklepovic, Harry D Bear, John R Subjeck, Elizabeth Repasky, Chunqing Guo, Xiang-Yang Wang

Review

Tumor-associated macrophages: potential therapeutic strategies and future prospects in cancer (27 January, 2021)
Chunxiao Li, Xiaofei Xu, Shuhua Wei, Ping Jiang, Lixiang Xue, Junjie Wang
Mechanisms underlying low-clinical responses to PD-1/PD-L1 blocking antibodies in immunotherapy of cancer: a key role of exosomal PD-L1 (20 January, 2021)
Zi Yin, Min Yu, Tingting Ma, Chuanzhao Zhang, Shanzhou Huang, Mohammad Reza Karimzadeh, Amir Abaas Momtazi-Borojeni, Sheng Chen
Rethinking immune checkpoint blockade: ‘Beyond the T cell’ (19 January, 2021)
Xiuting Liu, Graham D Hogg, David G DeNardo
Targeting immunogenic cancer cell death by photodynamic therapy: past, present and future (11 January, 2021)
Razan Alzeibak, Tatiana A. Mishchenko, Natalia Y. Shilyagina, Irina V. Balalaeva, Maria V. Vedunova, Dmitri V. Krysko

Correction

Correction: Combination checkpoint blockade for metastatic cutaneous malignancies in kidney transplant recipients
(26 January, 2021) Free
Correction: Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of lymphoma
(18 January, 2021)

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Table of contents

January 2021 - Volume 9 - 1

Basic tumor immunology

Case report

Clinical/translational cancer immunotherapy

Commentary

Immune cell therapies and immune cell engineering

Immunotherapy biomarkers

Oncolytic and local immunotherapy

Review

Correction

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Table of contents

January 2021 - Volume 9 - 1

Basic tumor immunology

Case report

Clinical/translational cancer immunotherapy

Commentary

Immune cell therapies and immune cell engineering

Immunotherapy biomarkers

Oncolytic and local immunotherapy

Review

Correction