Table of contents

Basic tumor immunology

• Original research: Tumor-associated macrophages induced spheroid formation by CCL18-ZEB1-M-CSF feedback loop to promote transcoelomic metastasis of ovarian cancer (27 December, 2021)

  Lingli Long, Yue Hu, Tengfei Long, Xiaofang Lu, Ying Tuo, Yubing Li, Min Wang, Zunfu Ke
• Original research: Distinct exhaustion features of T lymphocytes shape the tumor-immune microenvironment with therapeutic implication in patients with non-small-cell lung cancer (14 December, 2021)

  Chang Gon Kim, Gamin Kim, Kyung Hwan Kim, Seyeon Park, Sunhye Shin, Dahee Yeo, Hyo Sup Shim, Hong In Yoon, Seong Yong Park, Sang-Jun Ha, Hye Ryun Kim
• Original research:

  Combinatorial immunotherapy induces tumor-infiltrating CD8⁺ T cells with distinct functional, migratory, and stem-like properties

  (13 December, 2021)

  Natalija Van Braeckel-Budimir, Joseph Samuel Dolina, Jie Wei, Xiao Wang, Shih-Hsun Chen, Pamela Santiago, Guanghuan Tu, Luca Micci, Amir A Al-Khami, Sophia Pfister, Sripad Ram, Purnima Sundar, Graham Thomas, Hua Long, Wenjing Yang, Shobha Potluri, Shahram Salek-Ardakani
• Original research: Genomic and transcriptomic characterization of heterogeneous immune subgroups of microsatellite instability-high colorectal cancers (13 December, 2021)

  Jung Ho Kim, Mi-Kyoung Seo, Ji Ae Lee, Seung-Yeon Yoo, Hyeon Jeong Oh, Hyundeok Kang, Nam-Yun Cho, Jeong Mo Bae, Gyeong Hoon Kang, Sangwoo Kim
• Original research: Genomic profiles and their associations with TMB, PD-L1 expression, and immune cell infiltration landscapes in synchronous multiple primary lung cancers (9 December, 2021)

  Chunhong Hu, Lishu Zhao, Wenliang Liu, Songqing Fan, Junqi Liu, Yuxuan Liu, Xiaohan Liu, Long Shu, Xianling Liu, Ping Liu, Chao Deng, Zhenhua Qiu, Chen Chen, Yi Jiang, Qingchun Liang, Lingling Yang, Yang Shao, Qiongzhi He, Danlei Yu, Yue Zeng, Yizheng Li, Yue Pan, Sujuan Zhang, Shenghao Shi, Yurong Peng, Fang Wu
• Original research: Uncoupled biological and chronological aging of neutrophils in cancer promotes tumor progression (7 December, 2021)

  Laura A Mittmann, Florian Haring, Johanna B Schaubächer, Roman Hennel, Bojan Smiljanov, Gabriele Zuchtriegel, Martin Canis, Olivier Gires, Fritz Krombach, Lesca Holdt, Sven Brandau, Thomas Vogl, Kirsten Lauber, Bernd Uhl, Christoph A Reichel
• Original research:

  Immunization with short peptide particles reveals a functional CD8⁺ T-cell neoepitope in a murine renal carcinoma model

  (3 December, 2021)

  Xuedan He, Shiqi Zhou, Melissa Dolan, Yuhao Shi, Jianxin Wang, Breandan Quinn, Dushyant Jahagirdar, Wei-Chiao Huang, Moriya Tsuji, Roberto Pili, Fumito Ito, Joaquin Ortega, Scott I Abrams, John M L Ebos, Jonathan F Lovell
• Original research: Switch receptor T3/28 improves long-term persistence and antitumor efficacy of CAR-T cells (1 December, 2021)

  Songbo Zhao, Chunhua Wang, Ping Lu, Yalin Lou, Huimin Liu, Ting Wang, Shanshan Yang, Ziyou Bao, Lin Han, Xiaohong Liang, Chunhong Ma, Lifen Gao