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GD2 redirected CAR T and activated NK-cell-mediated secretion of IFNγ overcomes MYCN-dependent IDO1 inhibition, contributing to neuroblastoma cell immune escape

Authors

  • Matteo Caforio Department of Hematology/Oncology and Gene and Cell Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, ItalyDepartement of Biochemical Sciences "A Rossi Fanelli", Sapienza University of Rome, Rome, Italy PubMed articlesGoogle scholar articles
  • Cristina Sorino SAFU Laboratory, Department of Research, Advanced Diagnostic, and Technological Innovation, Istituto Regina Elena Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy, Italy PubMed articlesGoogle scholar articles
  • Ignazio Caruana Department of Hematology/Oncology and Gene and Cell Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy PubMed articlesGoogle scholar articles
  • Gerrit Weber Department of Hematology/Oncology and Gene and Cell Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy PubMed articlesGoogle scholar articles
  • Antonio Camera Department of Hematology/Oncology and Gene and Cell Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy PubMed articlesGoogle scholar articles
  • Loredana Cifaldi Academic Department of Pediatrics (DPUO), IRCCS Bambino Gesù Children's Hospistal, Rome, ItalyDepartment of Clical Sciences and Translational Medicine, University of Tor Vergata, Rome, Italy PubMed articlesGoogle scholar articles
  • Biagio De Angelis Department of Hematology/Oncology and Gene and Cell Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy PubMed articlesGoogle scholar articles
  • Francesca Del Bufalo Department of Hematology/Oncology and Gene and Cell Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy PubMed articlesGoogle scholar articles
  • Alessia Vitale Division of Metabolism and Research Unit of Metabolic Biochemistry, IRCCS Bambino gesù Children's Hospital, Rome, Italy PubMed articlesGoogle scholar articles
  • Bianca Maria Goffredo Division of Metabolism and Research Unit of Metabolic Biochemistry, IRCCS Bambino gesù Children's Hospital, Rome, Italy PubMed articlesGoogle scholar articles
  • Rita De Vito Department of Laboratories, Pathology Unit, IRCCS Bambino Gesù Children's Hospital, Rome, Italy PubMed articlesGoogle scholar articles
  • Doriana Fruci Department of Hematology/Oncology and Gene and Cell Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy PubMed articlesGoogle scholar articles
  • Concetta Quintarelli Department of Hematology/Oncology and Gene and Cell Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, ItalyDepartyment of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy PubMed articlesGoogle scholar articles
  • Maurizio Fanciulli SAFU Laboratory, Department of Research, Advanced Diagnostic, and Technological Innovation, Istituto Regina Elena Istituto di Ricovero e Cura a Carattere Scientifico, Rome, Italy, Italy PubMed articlesGoogle scholar articles
  • Franco Locatelli Department of Hematology/Oncology and Gene and Cell Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, ItalyDepartment of Pediatrics, Sapienza University of Rome, Rome, Italy PubMed articlesGoogle scholar articles
  • Valentina Folgiero Department of Hematology/Oncology and Gene and Cell Therapy, IRCCS Bambino Gesù Children's Hospital, Rome, Italy PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Valentina Folgiero; valentina.folgiero{at}opbg.net
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Citation

Caforio M, Sorino C, Caruana I, et al
GD2 redirected CAR T and activated NK-cell-mediated secretion of IFNγ overcomes MYCN-dependent IDO1 inhibition, contributing to neuroblastoma cell immune escape

Publication history

  • Accepted January 7, 2021
  • First published March 18, 2021.
Online issue publication 
February 10, 2022

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