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  • Prognostic significance of myeloid immune cells and their spatial distribution in the colorectal cancer microenvironment

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Immunotherapy biomarkers
Original research
Prognostic significance of myeloid immune cells and their spatial distribution in the colorectal cancer microenvironment

Authors

  • Juha P Väyrynen Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, and University of Oulu, Oulu, FinlandDepartment of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USAProgram in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Koichiro Haruki Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USAProgram in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USADepartment of Surgery, Jikei University School of Medicine, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Sara A Väyrynen Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Mai Chan Lau Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Andressa Dias Costa Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Jennifer Borowsky Conjoint Gastroenterology Department, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia PubMed articlesGoogle scholar articles
  • Melissa Zhao Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Tomotaka Ugai Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USADepartment of Epidemiology, Harvard University T.H. Chan School of Public Health, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Junko Kishikawa Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Naohiko Akimoto Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Rong Zhong Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Shanshan Shi Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Tzuu-Wang Chang Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Kenji Fujiyoshi Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Kota Arima Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Tyler S Twombly Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Annacarolina Da Silva Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Mingyang Song Department of Nutrition, Harvard University T.H. Chan School of Public Health, Boston, Massachusetts, USAClinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USADivision of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Kana Wu Department of Epidemiology, Harvard University T.H. Chan School of Public Health, Boston, Massachusetts, USADepartment of Nutrition, Harvard University T.H. Chan School of Public Health, Boston, Massachusetts, USAChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Xuehong Zhang Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Andrew T Chan Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USADivision of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USAChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USADepartment of Immunology and Infectious Diseases, Harvard University T.H. Chan School of Public Health, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Reiko Nishihara Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USADepartment of Epidemiology, Harvard University T.H. Chan School of Public Health, Boston, Massachusetts, USADepartment of Nutrition, Harvard University T.H. Chan School of Public Health, Boston, Massachusetts, USADepartment of Biostatistics, Harvard University T.H. Chan School of Public Health, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Charles S Fuchs Yale University Yale Cancer Center, New Haven, Connecticut, USADepartment of Medicine, Yale School of Medicine, New Haven, Connecticut, USASmilow Cancer Hospital, New Haven, Connecticut, USA PubMed articlesGoogle scholar articles
  • Jeffrey A Meyerhardt Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Marios Giannakis Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USABroad Institute of MIT and Harvard, Cambridge, Massachusetts, USADepartment of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Shuji Ogino Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USADepartment of Epidemiology, Harvard University T.H. Chan School of Public Health, Boston, Massachusetts, USABroad Institute of MIT and Harvard, Cambridge, Massachusetts, USACancer Immunology and Cancer Epidemiology Programs, Dana-Farber Harvard Cancer Center, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Jonathan A Nowak Program in MPE Molecular Pathological Epidemiology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Jonathan A Nowak; janowak{at}bwh.harvard.edu; Dr Shuji Ogino; sogino{at}bwh.harvard.edu
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Citation

Väyrynen JP, Haruki K, Väyrynen SA, et al
Prognostic significance of myeloid immune cells and their spatial distribution in the colorectal cancer microenvironment
Journal for ImmunoTherapy of Cancer 2021;9:e002297. doi: 10.1136/jitc-2020-002297

Publication history

  • Accepted March 18, 2021
  • First published April 30, 2021.
Online issue publication 
May 06, 2021

  • Supplementary Data

    This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.