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Immunotherapy biomarkers
Original research
Single-cell multiomics dissection of basal and antigen-specific activation states of CD19-targeted CAR T cells

Authors

  • Zhiliang Bai Department of Biomedical Engineering, Yale University, New Haven, Connecticut, USA State Key Laboratory of Precision Measurement Technology and Instrument, Tianjin University, Tianjin, China PubMed articlesGoogle scholar articles
  • Stefan Lundh Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA PubMed articlesGoogle scholar articles
  • Dongjoo Kim Department of Biomedical Engineering, Yale University, New Haven, Connecticut, USA PubMed articlesGoogle scholar articles
  • Steven Woodhouse Department of Genetics and Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, USA PubMed articlesGoogle scholar articles
  • David M Barrett Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA Departments of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA PubMed articlesGoogle scholar articles
  • Regina M Myers Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA PubMed articlesGoogle scholar articles
  • Stephan A Grupp Division of Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA Departments of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA PubMed articlesGoogle scholar articles
  • Marcela V Maus Cellular Immunotherapy Program and Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Carl H June Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA PubMed articlesGoogle scholar articles
  • Pablo G Camara Department of Genetics and Institute for Biomedical Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, USA PubMed articlesGoogle scholar articles
  • J Joseph Melenhorst Center for Cellular Immunotherapies, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA PubMed articlesGoogle scholar articles
  • Rong Fan Department of Biomedical Engineering, Yale University, New Haven, Connecticut, USA Yale Stem Cell Center and Yale Cancer Center, Yale School of Medicine, New Haven, Connecticut, USA PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Rong Fan; rong.fan{at}yale.edu
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Citation

Bai Z, Lundh S, Kim D, et al
Single-cell multiomics dissection of basal and antigen-specific activation states of CD19-targeted CAR T cells
Journal for ImmunoTherapy of Cancer 2021;9:e002328. doi: 10.1136/jitc-2020-002328

Publication history

  • Accepted April 20, 2021
  • First published May 18, 2021.
Online issue publication 
May 18, 2021

  • Supplementary Data

    This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

  • Supplementary Data

    This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

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Copyright information

© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.