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Basic tumor immunology
Original research
IGF1 receptor inhibition amplifies the effects of cancer drugs by autophagy and immune-dependent mechanisms

Authors

  • Qi Wu Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, ChinaCentre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, FranceMetabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France PubMed articlesGoogle scholar articles
  • Ai-Ling Tian Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, FranceMetabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, FranceFaculty of Medicine, Université Paris Saclay, Kremlin Bicêtre, France PubMed articlesGoogle scholar articles
  • Bei Li Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China PubMed articlesGoogle scholar articles
  • Marion Leduc Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, FranceMetabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France PubMed articlesGoogle scholar articles
  • Sabrina Forveille Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, FranceMetabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France PubMed articlesGoogle scholar articles
  • Peter Hamley Samsara Therapeutics Ltd, Oxford, UK PubMed articlesGoogle scholar articles
  • Warren Galloway Samsara Therapeutics Ltd, Oxford, UK PubMed articlesGoogle scholar articles
  • Wei Xie Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, FranceMetabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France PubMed articlesGoogle scholar articles
  • Peng Liu Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, FranceMetabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France PubMed articlesGoogle scholar articles
  • Liwei Zhao Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, FranceMetabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France PubMed articlesGoogle scholar articles
  • Shuai Zhang Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, FranceMetabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, FranceFaculty of Medicine, Université Paris Saclay, Kremlin Bicêtre, France PubMed articlesGoogle scholar articles
  • Pan Hui Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, FranceMetabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, FranceFaculty of Medicine, Université Paris Saclay, Kremlin Bicêtre, France PubMed articlesGoogle scholar articles
  • Frank Madeo Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, AustriaBioTechMed-Graz, Graz, AustriaField of Excellence BioHealth, University of Graz, Graz, Austria PubMed articlesGoogle scholar articles
  • Yi Tu Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, China PubMed articlesGoogle scholar articles
  • Oliver Kepp Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, FranceMetabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France PubMed articlesGoogle scholar articles
  • Guido Kroemer Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, Inserm U1138, Institut Universitaire de France, Paris, FranceMetabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, FranceSuzhou Institute for Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, Jiangsu, ChinaPôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, FranceKarolinska Institutet, Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Oliver Kepp; captain.olsen{at}gmail.com; Professor Yi Tu; ty701105{at}163.com; Prof Guido Kroemer; kroemer{at}orange.fr
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Citation

Wu Q, Tian A, Li B, et al
IGF1 receptor inhibition amplifies the effects of cancer drugs by autophagy and immune-dependent mechanisms
Journal for ImmunoTherapy of Cancer 2021;9:e002722. doi: 10.1136/jitc-2021-002722

Publication history

  • Accepted May 4, 2021
  • First published June 14, 2021.
Online issue publication 
June 14, 2021

  • Supplementary Data

    This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

  • Supplementary Data

    This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.