Journal for ImmunoTherapy of Cancer: 9 (7)

Basic tumor immunology

Original research: Statin-mediated inhibition of RAS prenylation activates ER stress to enhance the immunogenicity of KRAS mutant cancer (30 July, 2021)
Gi-Hoon Nam, Minsu Kwon, Hanul Jung, Eunbyeol Ko, Seong A Kim, Yoonjeong Choi, Su Jeong Song, Seohyun Kim, Yeji Lee, Gi Beom Kim, Jihoon Han, Jiwan Woo, Yakdol Cho, Cherlhyun Jeong, Seung-Yoon Park, Thomas M. Roberts, Yong Beom Cho, In-San Kim
Original research: Overexpression of CD200 is a stem cell-specific mechanism of immune evasion in AML (29 July, 2021)
Shelley Herbrich, Natalia Baran, Tianyu Cai, Connie Weng, Marisa J L Aitken, Sean M Post, Jared Henderson, Chunhua Shi, Ondrej Havranek, Guillame Richard-Carpentier, Guy Sauvageau, Keith Baggerly, Gheath Al-Atrash, R Eric Davis, Naval Daver, Dongxing Zha, Marina Konopleva
Original research:
Tryptophan potentiates CD8⁺ T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation
(29 July, 2021)
Rui Qin, Chen Zhao, Chen-Ji Wang, Wei Xu, Jian-Yuan Zhao, Yan Lin, Yi-Yuan Yuan, Peng-Cheng Lin, Yao Li, Shimin Zhao, Yan Huang
Original research: GCH1 induces immunosuppression through metabolic reprogramming and IDO1 upregulation in triple-negative breast cancer (19 July, 2021)
Jin-Li Wei, Si-Yu Wu, Yun-Song Yang, Yi Xiao, Xi Jin, Xiao-En Xu, Xin Hu, Da-Qiang Li, Yi-Zhou Jiang, Zhi-Ming Shao
Original research:
Tumor rejection in Cblb^−/− mice depends on IL-9 and Th9 cells
(16 July, 2021)
Oliver Schanz, Isabelle Cornez, Sowmya Parampalli Yajnanarayana, Friederike Sophie David, Sebastian Peer, Thomas Gruber, Peter Krawitz, Peter Brossart, Annkristin Heine, Jenny Landsberg, Gottfried Baier, Dominik Wolf
Original research: Oral SMEDDS promotes lymphatic transport and mesenteric lymph nodes target of chlorogenic acid for effective T-cell antitumor immunity (16 July, 2021)
Jun Ye, Yue Gao, Ming Ji, Yanfang Yang, Zhaohui Wang, Baolian Wang, Jing Jin, Ling Li, Hongliang Wang, Xiaoyan Xu, Hengfeng Liao, Chunfang Lian, Yaqi Xu, Renjie Li, Tong Sun, Lili Gao, Yan Li, Xiaoguang Chen, Yuling Liu
Original research:
PD-1⁺CXCR5⁻CD4⁺ Th-CXCL13 cell subset drives B cells into tertiary lymphoid structures of nasopharyngeal carcinoma
(12 July, 2021)
Jiang-Ping Li, Chang-You Wu, Ming-Yuan Chen, Shang-Xin Liu, Shu-Mei Yan, Yin-Feng Kang, Cong Sun, Jennifer R Grandis, Mu-Sheng Zeng, Qian Zhong
Original research:
Escherichia coli adhesin protein-conjugated thermal responsive hybrid nanoparticles for photothermal and immunotherapy against cancer and its metastasis
(6 July, 2021)
Juyoung Hwang, Wei Zhang, Hae-Bin Park, Dhananjay Yadav, Yong Hyun Jeon, Jun-O Jin
Original research: Chemoradiation triggers antitumor Th1 and tissue resident memory-polarized immune responses to improve immune checkpoint inhibitors therapy (6 July, 2021)
Elodie Lauret Marie Joseph, Amos Kirilovsky, Benoît Lecoester, Carine El Sissy, Laura Boullerot, Laurie Rangan, Amélie Marguier, Florent Tochet, Magalie Dosset, Jihane Boustani, Patrice Ravel, Romain Boidot, Laurie Spehner, Nacilla Haicheur-Adjouri, Florence Marliot, Jean-René Pallandre, Francis Bonnefoy, Viorel Scripcariu, Marc Van den Eynde, Emmanuel Cornillot, Céline Mirjolet, Franck Pages, Olivier Adotevi
Original research:
Expression of KLRG1 and CD127 defines distinct CD8⁺ subsets that differentially impact patient outcome in follicular lymphoma
(5 July, 2021)
Hongyan Wu, Xinyi Tang, Hyo Jin Kim, Shahrzad Jalali, Joshua C Pritchett, Jose C Villasboas, Anne J Novak, Zhi-Zhang Yang, Stephen M Ansell
Original research: Determinants of response to daratumumab in Epstein-Barr virus-positive natural killer and T-cell lymphoma (2 July, 2021)
Nurulhuda Mustafa, Adina Huey Fang Nee, Jing Yuan Chooi, Sabrina Hui Min Toh, Tae-Hoon Chung, Viknesvaran Selvarajan, Shuangyi Fan, Siok Bian Ng, Michelle Poon, Esther Chan, Joanne Lee, Yen Lin Chee, Anand D Jeyasekharan, Longen Zhou, Jennifer Yang, Wee Joo Chng

Case report

Pembrolizumab-induced cytokine release syndrome in a patient with metastatic lung adenocarcinoma: a case report (30 July, 2021)
Paul Sackstein, Jacob Zaemes, Chul Kim
Thrombopoietin receptor agonists for acquired thrombocytopenia following anti-CD19 CAR-T-cell therapy: a case report (16 July, 2021)
Rebecca Baur, Regina Jitschin, Soraya Kharboutli, Andrej Stoll, Simon Völkl, Maike Büttner-Herold, Daniela Schmidt, Wolf Rösler, Andreas Mackensen, Dimitrios Mougiakakos
Newly developed pseudogout arthritis after therapy with MAGE-A4 directed TCR T cells responded to treatment with tocilizumab (7 July, 2021)
Sang T. Kim, Jean Tayar, Siqing Fu, Danxia Ke, Elliot Norry, Amy Sun, Juli Miller, David S. Hong
Evaluating T-cell cross-reactivity between tumors and immune-related adverse events with TCR sequencing: pitfalls in interpretations of functional relevance (6 July, 2021)
Tricia Cottrell, Jiajia Zhang, Boyang Zhang, Genevieve J Kaunitz, Poromendro Burman, Hok-Yee Chan, Franco Verde, Jody E Hooper, Hans Hammers, Mohamad E Allaf, Hongkai Ji, Janis Taube, Kellie N Smith
Early rise in brain damage markers and high ICOS expression in CD4+ and CD8+ T cells during checkpoint inhibitor-induced encephalomyelitis (2 July, 2021)
Sara Bjursten, Ankur Pandita, Zhiyuan Zhao, Charlotta Fröjd, Lars Ny, Christer Jensen, Tobias Ullerstam, Henrik Jespersen, Jan Borén, Malin Levin, Henrik Zetterberg, Anna Rudin, Max Levin

Clinical/translational cancer immunotherapy

Original research: Src/lck inhibitor dasatinib reversibly switches off cytokine release and T cell cytotoxicity following stimulation with T cell bispecific antibodies (29 July, 2021)
Gabrielle Leclercq, Hélène Haegel, Anneliese Schneider, Anna Maria Giusti, Estelle Marrer-Berger, Christophe Boetsch, Antje-Christine Walz, Vesna Pulko, Johannes Sam, John Challier, Cristiano Ferlini, Alex Odermatt, Pablo Umaña, Marina Bacac, Christian Klein
Original research: Durable responses in patients with genitourinary cancers following immune checkpoint therapy rechallenge after moderate-to-severe immune-related adverse events (29 July, 2021)
Bilal A Siddiqui, Jinesh S Gheeya, Rohit Goswamy, Tharakeswara K Bathala, Devaki Shilpa Surasi, Jianjun Gao, Amishi Shah, Matthew T Campbell, Pavlos Msaouel, Sangeeta Goswami, Jennifer Wang, Amado J Zurita, Eric Jonasch, Paul G Corn, Ana M Aparicio, Arlene O Siefker-Radtke, Padmanee Sharma, Sumit K Subudhi, Nizar Tannir
Original research: WDR5-H3K4me3 epigenetic axis regulates OPN expression to compensate PD-L1 function to promote pancreatic cancer immune escape (29 July, 2021)
Chunwan Lu, Zhuoqi Liu, John D Klement, Dafeng Yang, Alyssa D Merting, Dakota Poschel, Thomas Albers, Jennifer L Waller, Huidong Shi, Kebin Liu
Original research: MYC suppresses STING-dependent innate immunity by transcriptionally upregulating DNMT1 in triple-negative breast cancer (28 July, 2021)
Si-Yu Wu, Yi Xiao, Jin-Li Wei, Xiao-En Xu, Xi Jin, Xin Hu, Da-Qiang Li, Yi-Zhou Jiang, Zhi-Ming Shao
Original research: Homocitrullination of lysine residues mediated by myeloid-derived suppressor cells in the tumor environment is a target for cancer immunotherapy (28 July, 2021)
Katherine W Cook, Wei Xue, Peter Symonds, Ian Daniels, Mohamed Gijon, David Boocock, Clare Coveney, Amanda K Miles, Sabaria Shah, Suha Atabani, Ruhul H Choudhury, Poonam Vaghela, Daisy Weston, Rachael L Metheringham, Victoria A Brentville, Lindy G Durrant
Original research: PD-L1 targeting and subclonal immune escape mediated by PD-L1 mutations in metastatic colorectal cancer (27 July, 2021)
Alexander Stein, Donjete Simnica, Christoph Schultheiß, Rebekka Scholz, Joseph Tintelnot, Eray Gökkurt, Lisa von Wenserski, Edith Willscher, Lisa Paschold, Markus Sauer, Sylvie Lorenzen, Jorge Riera-Knorrenschild, Reinhard Depenbusch, Thomas J Ettrich, Steffen Dörfel, Salah-Eddin Al-Batran, Meinolf Karthaus, Uwe Pelzer, Lisa Waberer, Axel Hinke, Marcus Bauer, Chiara Massa, Barbara Seliger, Claudia Wickenhauser, Carsten Bokemeyer, Susanna Hegewisch-Becker, Mascha Binder
Original research: First-line avelumab in a cohort of 116 patients with metastatic Merkel cell carcinoma (JAVELIN Merkel 200): primary and biomarker analyses of a phase II study (23 July, 2021)
Sandra P D'Angelo, Celeste Lebbé, Laurent Mortier, Andrew S Brohl, Nicola Fazio, Jean-Jacques Grob, Natalie Prinzi, Glenn J Hanna, Jessica C Hassel, Felix Kiecker, Sara Georges, Barbara Ellers-Lenz, Parantu Shah, Gülseren Güzel, Paul Nghiem
Original research:
CX-072 (pacmilimab), a Probody^® PD-L1 inhibitor, in advanced or recurrent solid tumors (PROCLAIM-CX-072): an open-label dose-finding and first-in-human study
(23 July, 2021)
Aung Naing, Fiona Thistlethwaite, Elisabeth G.E. De Vries, Ferry A.L.M. Eskens, Nataliya Uboha, Patrick A. Ott, Patricia LoRusso, Javier Garcia-Corbacho, Valentina Boni, Johanna Bendell, Karen A. Autio, Manreet Randhawa, Greg Durm, Marta Gil-Martin, Mark Stroh, Alison L. Hannah, Hendrik-Tobias Arkenau, Alexander Spira
Original research: CX-072 (pacmilimab), a Probody PD-L1 inhibitor, in combination with ipilimumab in patients with advanced solid tumors (PROCLAIM-CX-072): a first-in-human, dose-finding study (23 July, 2021)
Rachel E Sanborn, Omid Hamid, Elisabeth GE de Vries, Patrick A Ott, Javier Garcia-Corbacho, Valentina Boni, Johanna Bendell, Karen A Autio, Daniel C Cho, Ruth Plummer, Mark Stroh, Lawrence Lu, Fiona Thistlethwaite
p38 MAPK signaling in M1 macrophages results in selective elimination of M2 macrophages by MEK inhibition (20 July, 2021)
Daniel Baumann, Jennifer Drebant, Tanja Hägele, Luisa Burger, Clara Serger, Claudia Lauenstein, Przemyslaw Dudys, Gerrit Erdmann, Rienk Offringa
Original research: Individualized genetic makeup that controls natural killer cell function influences the efficacy of isatuximab immunotherapy in patients with multiple myeloma (16 July, 2021)
Haibo Sun, Thomas G Martin, John Marra, Denice Kong, Jonathon Keats, Sandrine Macé, Marielle Chiron, Jeffrey L Wolf, Jeffrey M Venstrom, Raja Rajalingam
Original research: Innovative therapeutic strategy for B-cell malignancies that combines obinutuzumab and cytokine-induced killer cells (16 July, 2021)
Anna Dalla Pietà, Elisa Cappuzzello, Pierangela Palmerini, Annavera Ventura, Andrea Visentin, Giuseppe Astori, Katia Chieregato, Valentina Mozzo, Omar Perbellini, Maria Chiara Tisi, Livio Trentin, Carlo Visco, Marco Ruggeri, Roberta Sommaggio, Antonio Rosato
Original research: Multi-institutional TSA-amplified Multiplexed Immunofluorescence Reproducibility Evaluation (MITRE) Study (15 July, 2021)
Janis M Taube, Kristin Roman, Elizabeth L Engle, Chichung Wang, Carmen Ballesteros-Merino, Shawn M Jensen, John McGuire, Mei Jiang, Carla Coltharp, Bethany Remeniuk, Ignacio Wistuba, Darren Locke, Edwin R Parra, Bernard A Fox, David L Rimm, Cliff Hoyt
Original research:
CD11b⁺CTLA4⁺ myeloid cells are a key driver of tumor evasion in colorectal cancer
(14 July, 2021)
Hiroshi Imazeki, Yamato Ogiwara, Mami Kawamura, Narikazu Boku, Chie Kudo-Saito
Original research: Dichotomous impact of affinity on the function of T cell engaging bispecific antibodies (12 July, 2021)
Mathilde Poussin, Arlene Sereno, Xiufeng Wu, Flora Huang, Jason Manro, Shanshan Cao, Carmine Carpenito, Andrew Glasebrook, Daniel J Powell Jr, Stephen J Demarest
Original research: Neoantigen vaccination induces clinical and immunologic responses in non-small cell lung cancer patients harboring EGFR mutations (8 July, 2021)
Fenge Li, Ligang Deng, Kyle R Jackson, Amjad H Talukder, Arjun S Katailiha, Sherille D Bradley, Qingwei Zou, Caixia Chen, Chong Huo, Yulun Chiu, Matthew Stair, Weihong Feng, Aleksander Bagaev, Nikita Kotlov, Viktor Svekolkin, Ravshan Ataullakhanov, Natalia Miheecheva, Felix Frenkel, Yaling Wang, Minying Zhang, David Hawke, Ling Han, Shuo Zhou, Yan Zhang, Zhenglu Wang, William K Decker, Heather M Sonnemann, Jason Roszik, Marie-Andree Forget, Michael A Davies, Chantale Bernatchez, Cassian Yee, Roland Bassett, Patrick Hwu, Xueming Du, Gregory Lizee
Original research: Exploiting off-target effects of estrogen deprivation to sensitize estrogen receptor negative breast cancer to immune killing (8 July, 2021)
Benjamin Wolfson, Michelle R Padget, Jeffrey Schlom, James W Hodge
Original research: Clinical outcomes of patients with corticosteroid refractory immune checkpoint inhibitor-induced enterocolitis treated with infliximab (7 July, 2021)
James L Alexander, Hajir Ibraheim, Bhavisha Sheth, Jessica Little, Muhammad Saheb Khan, Camellia Richards, Nikki Hunter, Dharmisha Chauhan, Raguprakash Ratnakumaran, Kathleen McHugh, David J Pinato, Paul Nathan, Julia Choy, Shanthini M Crusz, Andrew Furness, Samra Turajlic, Lisa Pickering, James Larkin, Julian P Teare, Sophie Papa, Ally Speight, Anand Sharma, Nick Powell
Original research: Metformin generates profound alterations in systemic and tumor immunity with associated antitumor effects (6 July, 2021)
Ratna Veeramachaneni, Wangjie Yu, Jared M Newton, Jan O Kemnade, Heath D Skinner, Andrew G Sikora, Vlad C Sandulache
Original research: Novel anti-4-1BB×PD-L1 bispecific antibody augments anti-tumor immunity through tumor-directed T-cell activation and checkpoint blockade (6 July, 2021)
Seongju Jeong, Eunyoung Park, Hyung-Don Kim, Eunsil Sung, Hyunjoo Kim, Jaehyoung Jeon, Youngkwang Kim, Ui-jung Jung, Yong-Gyu Son, Youngeun Hong, Hanbyul Lee, Shinai Lee, Yangmi Lim, Jonghwa Won, Minwoo Jeon, Shin Hwang, Lei Fang, Wenqing Jiang, Zhengyi Wang, Eui-Cheol Shin, Su-Hyung Park, Jaeho Jung
Original research: Phase 1 study of safety, tolerability and immunogenicity of the human telomerase (hTERT)-encoded DNA plasmids INO-1400 and INO-1401 with or without IL-12 DNA plasmid INO-9012 in adult patients with solid tumors (6 July, 2021)
Robert H Vonderheide, Kimberly A Kraynyak, Anthony F Shields, Autumn J McRee, Jennifer M Johnson, Weijing Sun, Ashish V Chintakuntlawar, Jan Pawlicki, Albert J Sylvester, Trevor McMullan, Robert Samuels, Joseph J Kim, David Weiner, Jean D Boyer, Matthew P Morrow, Laurent Humeau, Jeffrey M Skolnik
Original research: Ocular adverse events in PD-1 and PD-L1 inhibitors (5 July, 2021)
LeAnne Young, Shanda Finnigan, Howard Streicher, Helen X Chen, James Murray, H Nida Sen, Elad Sharon

Commentary

Author response to Cunha et al
(27 July, 2021)
Rivka R Colen, Christian Rolfo, Murat Ak, Mira Ayoub, Sara Ahmed, Nabil Elshafeey, Priyadarshini Mamindla, Pascal O Zinn, Chaan Ng, Raghu Vikram, Spyridon Bakas, Christine B Peterson, Jordi Rodon Ahnert, Vivek Subbiah, Daniel D Karp, Bettzy Stephen, Joud Hajjar, Aung Naing
Letter to the editor: radiomics analysis for predicting pembrolizumab response in patients with advanced rare cancers (27 July, 2021)
Mateus Trinconi Cunha, Vinicius Jardim Carvalho, Rafael Maffei Loureiro, Carlos Eduardo Brantis-de-Carvalho, Murilo Bicudo Cintra, Gilberto de Castro Junior
Search for effective treatments in patients with advanced refractory melanoma continues: can novel intratumoral therapies deliver? (26 July, 2021)
Yana G Najjar

Immunotherapy biomarkers

Original research: Modified Glasgow Prognostic Score associated with survival in metastatic renal cell carcinoma treated with immune checkpoint inhibitors (29 July, 2021)
Jacqueline T Brown, Yuan Liu, Julie M Shabto, Dylan Martini, Deepak Ravindranathan, Emilie Elise Hitron, Greta Anne Russler, Sarah Caulfield, Lauren Yantorni, Shreyas Subhash Joshi, Haydn Kissick, Kenneth Ogan, Bassel Nazha, Bradley C Carthon, Omer Kucuk, Wayne B Harris, Viraj A Master, Mehmet Asim Bilen
Original research: First-in-human DR5 PET reveals insufficient DR5 expression in patients with gastrointestinal cancer (22 July, 2021)
Shujing Wang, Hua Zhu, Yingjie Li, Jin Ding, Feng Wang, Lixin Ding, Xinyu Wang, Jun Zhao, Yan Zhang, Yunfeng Yao, Tong Zhou, Nan Li, Aiwen Wu, Zhi Yang
Original research:
Predictive value of 3′-deoxy-3′-¹⁸F-fluorothymidine PET in the early response to anti-programmed death-1 therapy in patients with advanced non-small cell lung cancer
(22 July, 2021)
Masayuki Sato, Yukihiro Umeda, Tetsuya Tsujikawa, Tetsuya Mori, Miwa Morikawa, Masaki Anzai, Yuko Waseda, Maiko Kadowaki, Yasushi Kiyono, Hidehiko Okazawa, Tamotsu Ishizuka
Original research: ATM/NEMO signaling modulates the expression of PD-L1 following docetaxel chemotherapy in prostate cancer (22 July, 2021)
Zongren Wang, Xueling Zhang, Wuguo Li, Qiao Su, Zhaoyang Huang, Xinyao Zhang, Haiqi Chen, Chengqiang Mo, Bin Huang, Wei Ou, Junxing Chen, Guangyin Zhao, Lingwu Chen, Lan Shao
Original research: DNA methylation-based prediction of response to immune checkpoint inhibition in metastatic melanoma (19 July, 2021)
Katharina Filipski, Michael Scherer, Kim N. Zeiner, Andreas Bucher, Johannes Kleemann, Philipp Jurmeister, Tabea I. Hartung, Markus Meissner, Karl H. Plate, Tim R. Fenton, Jörn Walter, Sascha Tierling, Bastian Schilling, Pia S. Zeiner, Patrick N. Harter
Original research: Immunogenomic determinants of tumor microenvironment correlate with superior survival in high-risk neuroblastoma (16 July, 2021)
Riyue Bao, Stefani Spranger, Kyle Hernandez, Yuanyuan Zha, Peter Pytel, Jason J Luke, Thomas F Gajewski, Samuel L Volchenboum, Susan L Cohn, Ami V Desai
Original research: Single-cell RNA sequencing reveals distinct cellular factors for response to immunotherapy targeting CD73 and PD-1 in colorectal cancer (12 July, 2021)
Miok Kim, Yong Ki Min, Jinho Jang, Hyejin Park, Semin Lee, Chang Hoon Lee

Immune cell therapies and immune cell engineering

Original research: High-affinity T-cell receptor specific for MyD88 L265P mutation for adoptive T-cell therapy of B-cell malignancies (30 July, 2021)
Özcan Çınar, Bernadette Brzezicha, Corinna Grunert, Peter Michael Kloetzel, Christin Beier, Caroline Anna Peuker, Ulrich Keller, Antonio Pezzutto, Antonia Busse
Original research: Direct identification of neoantigen-specific TCRs from tumor specimens by high-throughput single-cell sequencing (28 July, 2021)
Yong-Chen Lu, Zhili Zheng, Frank J Lowery, Jared J Gartner, Todd D Prickett, Paul F Robbins, Steven A Rosenberg
Challenges and next steps in the advancement of immunotherapy: summary of the 2018 and 2020 National Cancer Institute workshops on cell-based immunotherapy for solid tumors (15 July, 2021)
Laura K Fogli, Rosemarie Aurigemma, Connie L Sommers, Anju Singh, Kasia Bourcier, Marc S Ernstoff
Identification of neoantigen-reactive T lymphocytes in the peripheral blood of a patient with glioblastoma (15 July, 2021)
Vid Leko, Gal Cafri, Rami Yossef, Biman Paria, Victoria Hill, Devikala Gurusamy, Zhili Zheng, Jared J Gartner, Todd D Prickett, Stephanie L Goff, Paul Robbins, Yong-Chen Lu, Steven A Rosenberg
Original research: Influence of DM-sensitivity on immunogenicity of MHC class II restricted antigens (15 July, 2021)
Anna Luise Bernhardt, Julia Zeun, Miriam Marecek, Hannah Reimann, Sascha Kretschmann, Judith Bausenwein, Edith D van der Meijden, Margarete M Karg, Tabea Haug, Lisa Meintker, Gloria Lutzny-Geier, Andreas Mackensen, Anita N Kremer
Original research:
Combinatorial immunotherapy of N-803 (IL-15 superagonist) and dinutuximab with ex vivo expanded natural killer cells significantly enhances in vitro cytotoxicity against GD2⁺ pediatric solid tumors and in vivo survival of xenografted immunodeficient NSG mice
(8 July, 2021)
Yaya Chu, Gaurav Nayyar, Susiyan Jiang, Jeremy M. Rosenblum, Patrick Soon-Shiong, Jeffrey T Safrit, Dean A. Lee, Mitchell S. Cairo
Original research: Clinical efficacy of T-cell therapy after short-term BRAF-inhibitor priming in patients with checkpoint inhibitor-resistant metastatic melanoma (1 July, 2021)
Troels Holz Borch, Katja Harbst, Aynal Haque Rana, Rikke Andersen, Evelina Martinenaite, Per Kongsted, Magnus Pedersen, Morten Nielsen, Julie Westerlin Kjeldsen, Anders Handrup Kverneland, Martin Lauss, Lisbet Rosenkrantz Hölmich, Helle Hendel, Özcan Met, Göran Jönsson, Marco Donia, Inge Marie Svane
Original research: Induction of EBV latent membrane protein-2A (LMP2A)-specific T cells and construction of individualized TCR-engineered T cells for EBV-associated malignancies (1 July, 2021)
Chaoting Zhang, Qin Tan, Shance Li, Luyan Shen, Jingtao Zhang, Ying Liu, Wenjun Yang, Zheming Lu

Oncolytic and local immunotherapy

Original research: Intratumoral talimogene laherparepvec injection with concurrent preoperative radiation in patients with locally advanced soft-tissue sarcoma of the trunk and extremities: phase IB/II trial (30 July, 2021)
Varun Monga, Benjamin J Miller, Munir Tanas, Sarag Boukhar, Bryan Allen, Carryn Anderson, Laura Stephens, Stacey Hartwig, Steven Varga, Jon Houtman, Lei Wang, Weizhou Zhang, Omar Jaber, Jon Thomason, David Kuehn, Maheen Rajput, Catherine Metz, K.D. Zamba, Sarah Mott, Chinemerem Abanonu, Sudershan Bhatia, Mohammed Milhem
Original research: Statins act as transient type I interferon inhibitors to enable the antitumor activity of modified vaccinia Ankara viral vectors (28 July, 2021)
Shirley Tenesaca, Marcos Vasquez, Maite Alvarez, Itziar Otano, Myriam Fernandez-Sendin, Claudia Augusta Di Trani, Nuria Ardaiz, Celia Gomar, Angela Bella, Fernando Aranda, José Medina-Echeverz, Ignacio Melero, Pedro Berraondo
Original research: Antiviral antibody responses to systemic administration of an oncolytic RNA virus: the impact of standard concomitant anticancer chemotherapies (22 July, 2021)
Victoria Roulstone, David Mansfield, Robert J Harris, Katie Twigger, Christine White, Johann de Bono, James Spicer, Sophia N Karagiannis, Richard Vile, Hardev Pandha, Alan Melcher, Kevin Harrington
Original research: GD2-directed bispecific trifunctional antibody outperforms dinutuximab beta in a murine model for aggressive metastasized neuroblastoma (20 July, 2021)
Felix Zirngibl, Sara M Ivasko, Laura Grunewald, Anika Klaus, Silke Schwiebert, Peter Ruf, Horst Lindhofer, Kathy Astrahantseff, Lena Andersch, Johannes H Schulte, Holger N Lode, Angelika Eggert, Kathleen Anders, Patrick Hundsdoerfer, Annette Künkele
Original research: CD137 and PD-L1 targeting with immunovirotherapy induces a potent and durable antitumor immune response in glioblastoma models (19 July, 2021)
Montserrat Puigdelloses, Marc Garcia-Moure, Sara Labiano, Virginia Laspidea, Marisol Gonzalez-Huarriz, Marta Zalacain, Lucia Marrodan, Naiara Martinez-Velez, Daniel De la Nava, Iker Ausejo, Sandra Hervás-Stubbs, Guillermo Herrador, ZhiHong Chen, Dolores Hambardzumyan, Ana Patino Garcia, Hong Jiang, Candelaria Gomez-Manzano, Juan Fueyo, Jaime Gállego Pérez-Larraya, Marta Alonso
Original research: Novel personalized cancer vaccine platform based on Bacillus Calmette-Guèrin (15 July, 2021)
Erkko Ylösmäki, Manlio Fusciello, Beatriz Martins, Sara Feola, Firas Hamdan, Jacopo Chiaro, Leena Ylösmäki, Matthew J Vaughan, Tapani Viitala, Prasad S Kulkarni, Vincenzo Cerullo
Original research: Co-delivery of novel bispecific and trispecific engagers by an amplicon vector augments the therapeutic effect of an HSV-based oncolytic virotherapy (6 July, 2021)
Divya Ravirala, Brandon Mistretta, Preethi H Gunaratne, Guangsheng Pei, Zhongming Zhao, Xiaoliu Zhang
Original research: Timing of steroid initiation and response rates to immune checkpoint inhibitors in metastatic cancer (5 July, 2021)
Diana V Maslov, Karine Tawagi, Madhav KC, Victoria Simenson, Helen Yuan, Cameron Parent, Adi Bamnolker, Richa Goel, Zoe Blake, Marc R Matrana, Daniel H Johnson
Original research: STING agonist loaded lipid nanoparticles overcome anti-PD-1 resistance in melanoma lung metastasis via NK cell activation (2 July, 2021)
Takashi Nakamura, Takanori Sato, Rikito Endo, Shun Sasaki, Naomichi Takahashi, Yusuke Sato, Mamoru Hyodo, Yoshihiro Hayakawa, Hideyoshi Harashima

Position article and guidelines

It’s not ‘just a tube of blood’: principles of protocol development, sample collection, staffing and budget considerations for blood-based biomarkers in immunotherapy studies (28 July, 2021)
Cindy Y Jiang, Zeqi Niu, Michael D Green, Lili Zhao, Shelby Raupp, Brittany Pannecouk, Dean E Brenner, Sunitha Nagrath, Nithya Ramnath
Consensus disease definitions for neurologic immune-related adverse events of immune checkpoint inhibitors (19 July, 2021)
Amanda C Guidon, Leeann B Burton, Bart K Chwalisz, James Hillis, Teilo H Schaller, Anthony A Amato, Allison Betof Warner, Priscilla K Brastianos, Tracey A Cho, Stacey L Clardy, Justine V Cohen, Jorg Dietrich, Michael Dougan, Christopher T Doughty, Divyanshu Dubey, Jeffrey M Gelfand, Jeffrey T Guptill, Douglas B Johnson, Vern C Juel, Robert Kadish, Noah Kolb, Nicole R LeBoeuf, Jenny Linnoila, Andrew L Mammen, Maria Martinez-Lage, Meghan J Mooradian, Jarushka Naidoo, Tomas G Neilan, David A Reardon, Krista M Rubin, Bianca D Santomasso, Ryan J Sullivan, Nancy Wang, Karin Woodman, Leyre Zubiri, William C Louv, Kerry L Reynolds
Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of urothelial cancer (15 July, 2021)
Matthew D Galsky, Arjun V Balar, Peter C Black, Matthew T Campbell, Gail S Dykstra, Petros Grivas, Shilpa Gupta, Christoper J Hoimes, Lidia P Lopez, Joshua J Meeks, Elizabeth R Plimack, Jonathan E Rosenberg, Neal Shore, Gary D Steinberg, Ashish M Kamat
Immune-related adverse events associated with immune checkpoint inhibitors: a call to action for collecting and sharing clinical trial and real-world data (2 July, 2021)
Kerry L Reynolds, Shaily Arora, Ravikumar Komandur Elayavilli, William C Louv, Teilo H Schaller, Aakanksha Khandelwal, Mace Rothenberg, Sean Khozin, Amanda C Guidon, Michael Dougan, Leyre Zubiri, Laura Petrillo, Meghan E Sise, Alexandra-Chloe Villani, Douglas B Johnson, Osama Rahma, Elad Sharon

Review

Mechanisms of regulatory T cell infiltration in tumors: implications for innovative immune precision therapies (30 July, 2021)
Shohei Koyama, Hiroyoshi Nishikawa
Adoptive cellular therapy in solid tumor malignancies: review of the literature and challenges ahead (23 July, 2021)
Kedar Kirtane, Hany Elmariah, Christine H Chung, Daniel Abate-Daga
Neutrophils in the era of immune checkpoint blockade (22 July, 2021)
Julien Faget, Solange Peters, Xavier Quantin, Etienne Meylan, Nathalie Bonnefoy
Clinical and immunologic implications of COVID-19 in patients with melanoma and renal cell carcinoma receiving immune checkpoint inhibitors (16 July, 2021)
Benjamin Switzer, John Haanen, Paul C Lorigan, Igor Puzanov, Samra Turajlic
Systematic review of combinations of targeted or immunotherapy in advanced solid tumors (2 July, 2021)
Aaron C Tan, Stephen J Bagley, Patrick Y Wen, Michael Lim, Michael Platten, Howard Colman, David M Ashley, Wolfgang Wick, Susan M Chang, Evanthia Galanis, Alireza Mansouri, Simon Khagi, Minesh P Mehta, Amy B Heimberger, Vinay K Puduvalli, David A Reardon, Solmaz Sahebjam, John Simes, Scott J Antonia, Don Berry, Mustafa Khasraw
Exercise and the immune system: taking steps to improve responses to cancer immunotherapy (2 July, 2021)
Michael P Gustafson, Courtney M Wheatley-Guy, Allison C Rosenthal, Dennis A Gastineau, Emmanuel Katsanis, Bruce D Johnson, Richard J Simpson

Main menu

Table of contents

July 2021 - Volume 9 - 7

Basic tumor immunology

Case report

Clinical/translational cancer immunotherapy

Commentary

Immunotherapy biomarkers

Immune cell therapies and immune cell engineering

Oncolytic and local immunotherapy

Position article and guidelines

Review

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Table of contents

July 2021 - Volume 9 - 7

Basic tumor immunology

Case report

Clinical/translational cancer immunotherapy

Commentary

Immunotherapy biomarkers

Immune cell therapies and immune cell engineering

Oncolytic and local immunotherapy

Position article and guidelines

Review