Article info

Original research
Statin-mediated inhibition of RAS prenylation activates ER stress to enhance the immunogenicity of KRAS mutant cancer

Authors

  • Gi-Hoon Nam Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of KoreaDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USADepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA PubMed articlesGoogle scholar articles
  • Minsu Kwon Department of Otorhinolaryngology-Head and Neck Surgery, Korea University Anam Hospital, Korea University College of Medicine, Seoul 02841, Republic of Korea PubMed articlesGoogle scholar articles
  • Hanul Jung Department of Otorhinolaryngology-Head and Neck Surgery, Korea University Anam Hospital, Korea University College of Medicine, Seoul 02841, Republic of Korea PubMed articlesGoogle scholar articles
  • Eunbyeol Ko Institute for Future Medicine, Samsung Medical Center, Seoul, Republic of Korea PubMed articlesGoogle scholar articles
  • Seong A Kim Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of KoreaKU-KIST Graduate School of Converging Science and Technology, Korea University, 145, Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea PubMed articlesGoogle scholar articles
  • Yoonjeong Choi Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of KoreaKU-KIST Graduate School of Converging Science and Technology, Korea University, 145, Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea PubMed articlesGoogle scholar articles
  • Su Jeong Song Institute for Future Medicine, Samsung Medical Center, Seoul, Republic of Korea PubMed articlesGoogle scholar articles
  • Seohyun Kim Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of KoreaKU-KIST Graduate School of Converging Science and Technology, Korea University, 145, Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea PubMed articlesGoogle scholar articles
  • Yeji Lee Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of KoreaKU-KIST Graduate School of Converging Science and Technology, Korea University, 145, Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea PubMed articlesGoogle scholar articles
  • Gi Beom Kim Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of KoreaKU-KIST Graduate School of Converging Science and Technology, Korea University, 145, Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea PubMed articlesGoogle scholar articles
  • Jihoon Han Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of KoreaKU-KIST Graduate School of Converging Science and Technology, Korea University, 145, Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea PubMed articlesGoogle scholar articles
  • Jiwan Woo Research Animal Resource Center, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea PubMed articlesGoogle scholar articles
  • Yakdol Cho Research Animal Resource Center, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea PubMed articlesGoogle scholar articles
  • Cherlhyun Jeong Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of KoreaKHU-KIST Department of Converging Science and Technology, Kyunghee University, Seoul 02447, Republic of Korea PubMed articlesGoogle scholar articles
  • Seung-Yoon Park Department of Biochemistry, School of Medicine, Dongguk University, Gyeongju 38066, Republic of Korea PubMed articlesGoogle scholar articles
  • Thomas M. Roberts Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USADepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02215, USA PubMed articlesGoogle scholar articles
  • Yong Beom Cho Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of KoreaDepartment of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea PubMed articlesGoogle scholar articles
  • In-San Kim Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of KoreaKU-KIST Graduate School of Converging Science and Technology, Korea University, 145, Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea PubMed articlesGoogle scholar articles
  1. Correspondence to In-San Kim; iskim14{at}kist.re.kr; Yong Beom Cho; yongbeom.cho{at}samsung.com
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Citation

Nam G, Kwon M, Jung H, et al
Statin-mediated inhibition of RAS prenylation activates ER stress to enhance the immunogenicity of KRAS mutant cancer

Publication history

  • Accepted July 8, 2021
  • First published July 30, 2021.
Online issue publication 
July 30, 2021
  • Supplementary Data

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