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  • WDR5-H3K4me3 epigenetic axis regulates OPN expression to compensate PD-L1 function to promote pancreatic cancer immune escape

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Clinical/translational cancer immunotherapy
Original research
WDR5-H3K4me3 epigenetic axis regulates OPN expression to compensate PD-L1 function to promote pancreatic cancer immune escape

Authors

  • Chunwan Lu School of Life Sciences, Tianjin University, Tianjin, China PubMed articlesGoogle scholar articles
  • Zhuoqi Liu Department of Biochemistry and Molecular Biology, Nanchang University, Nanchang, China PubMed articlesGoogle scholar articles
  • John D Klement Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia, USAGeorgia Cancer Center, Medical College of Georgia, Augusta, Georgia, USACharlie Norwood VA Medical Center, Augusta, Georgia, USA PubMed articlesGoogle scholar articles
  • Dafeng Yang Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia, USAGeorgia Cancer Center, Medical College of Georgia, Augusta, Georgia, USACharlie Norwood VA Medical Center, Augusta, Georgia, USA PubMed articlesGoogle scholar articles
  • Alyssa D Merting Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia, USAGeorgia Cancer Center, Medical College of Georgia, Augusta, Georgia, USACharlie Norwood VA Medical Center, Augusta, Georgia, USA PubMed articlesGoogle scholar articles
  • Dakota Poschel Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia, USAGeorgia Cancer Center, Medical College of Georgia, Augusta, Georgia, USACharlie Norwood VA Medical Center, Augusta, Georgia, USA PubMed articlesGoogle scholar articles
  • Thomas Albers Georgia Cancer Center, Medical College of Georgia, Augusta, Georgia, USA PubMed articlesGoogle scholar articles
  • Jennifer L Waller Department of Population Health Science, Medical College of Georgia, Augusta, Georgia, USA PubMed articlesGoogle scholar articles
  • Huidong Shi Georgia Cancer Center, Medical College of Georgia, Augusta, Georgia, USA PubMed articlesGoogle scholar articles
  • Kebin Liu Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, Georgia, USAGeorgia Cancer Center, Medical College of Georgia, Augusta, Georgia, USACharlie Norwood VA Medical Center, Augusta, Georgia, USA PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Kebin Liu; kliu{at}augusta.edu; Dr Chunwan Lu; Chunwanlu{at}tju.edu.cn
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Citation

Lu C, Liu Z, Klement JD, et al
WDR5-H3K4me3 epigenetic axis regulates OPN expression to compensate PD-L1 function to promote pancreatic cancer immune escape
Journal for ImmunoTherapy of Cancer 2021;9:e002624. doi: 10.1136/jitc-2021-002624

Publication history

  • Accepted June 29, 2021
  • First published July 29, 2021.
Online issue publication 
November 02, 2022

  • Supplementary Data

    This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.