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Basic tumor immunology
Original research
Tryptophan potentiates CD8+ T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation

Authors

  • Rui Qin State Key Laboratory of Genetic Engineering, School of Life Sciences and Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China PubMed articlesGoogle scholar articles
  • Chen Zhao State Key Laboratory of Genetic Engineering, School of Life Sciences and Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China PubMed articlesGoogle scholar articles
  • Chen-Ji Wang State Key Laboratory of Genetic Engineering, School of Life Sciences and Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China PubMed articlesGoogle scholar articles
  • Wei Xu NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Shanghai Key Laboratory of Metabolic Remodeling, Institute of Metabolism and Integrative Biology and Institutes of Biomedical Sciences, Shanghai, ChinaDepartment of Cardiology, Children's Hospital of Fudan University, Shanghai, China PubMed articlesGoogle scholar articles
  • Jian-Yuan Zhao NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Shanghai Key Laboratory of Metabolic Remodeling, Institute of Metabolism and Integrative Biology and Institutes of Biomedical Sciences, Shanghai, ChinaDepartment of Cardiology, Children's Hospital of Fudan University, Shanghai, China PubMed articlesGoogle scholar articles
  • Yan Lin NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Shanghai Key Laboratory of Metabolic Remodeling, Institute of Metabolism and Integrative Biology and Institutes of Biomedical Sciences, Shanghai, ChinaDepartment of Cardiology, Children's Hospital of Fudan University, Shanghai, China PubMed articlesGoogle scholar articles
  • Yi-Yuan Yuan NHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Shanghai Key Laboratory of Metabolic Remodeling, Institute of Metabolism and Integrative Biology and Institutes of Biomedical Sciences, Shanghai, ChinaDepartment of Cardiology, Children's Hospital of Fudan University, Shanghai, China PubMed articlesGoogle scholar articles
  • Peng-Cheng Lin Key Laboratory for Tibet Plateau Phytochemistry of Qinghai Province, College of Pharmacy, Qinghai University for Nationalities, Xining, China PubMed articlesGoogle scholar articles
  • Yao Li State Key Laboratory of Genetic Engineering, School of Life Sciences and Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China PubMed articlesGoogle scholar articles
  • Shimin Zhao State Key Laboratory of Genetic Engineering, School of Life Sciences and Obstetrics & Gynecology Hospital of Fudan University, Shanghai, ChinaNHC Key Lab of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Shanghai Key Laboratory of Metabolic Remodeling, Institute of Metabolism and Integrative Biology and Institutes of Biomedical Sciences, Shanghai, China PubMed articlesGoogle scholar articles
  • Yan Huang State Key Laboratory of Genetic Engineering, School of Life Sciences and Obstetrics & Gynecology Hospital of Fudan University, Shanghai, China PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Shimin Zhao; zhaosm{at}fudan.edu.cn; Dr Yao Li; yaoli{at}fudan.edu.cn; Dr Yan Huang; huangyan{at}fudan.edu.cn
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Citation

Qin R, Zhao C, Wang C, et al
Tryptophan potentiates CD8+ T cells against cancer cells by TRIP12 tryptophanylation and surface PD-1 downregulation
Journal for ImmunoTherapy of Cancer 2021;9:e002840. doi: 10.1136/jitc-2021-002840

Publication history

  • Accepted June 30, 2021
  • First published July 29, 2021.
Online issue publication 
November 02, 2022

  • Supplementary Data

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.