Article info

Original research
Cancer immunotherapy with PI3K and PD-1 dual-blockade via optimal modulation of T cell activation signal

Authors

  • Sho Isoyama Division of Cancer Immunology, Research Institute/Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center, Tokyo/Kashiwa, JapanDivision of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, JapanR&D Center, Zenyaku Kogyo Co Ltd, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Shigeyuki Mori Division of Cancer Immunology, Research Institute/Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center, Tokyo/Kashiwa, JapanR&D Center, Zenyaku Kogyo Co Ltd, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Daisuke Sugiyama Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan PubMed articlesGoogle scholar articles
  • Yasuhiro Kojima Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan PubMed articlesGoogle scholar articles
  • Yasuko Tada Division of Cancer Immunology, Research Institute/Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center, Tokyo/Kashiwa, Japan PubMed articlesGoogle scholar articles
  • Kohei Shitara Department of Gastroenterology and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan PubMed articlesGoogle scholar articles
  • Kunihiko Hinohara Department of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan PubMed articlesGoogle scholar articles
  • Shingo Dan Division of Molecular Pharmacology, Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan PubMed articlesGoogle scholar articles
  • Hiroyoshi Nishikawa Division of Cancer Immunology, Research Institute/Exploratory Oncology Research and Clinical Trial Center (EPOC), National Cancer Center, Tokyo/Kashiwa, JapanDepartment of Immunology, Nagoya University Graduate School of Medicine, Nagoya, Japan PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Hiroyoshi Nishikawa; hnishika{at}ncc.go.jp
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Citation

Isoyama S, Mori S, Sugiyama D, et al
Cancer immunotherapy with PI3K and PD-1 dual-blockade via optimal modulation of T cell activation signal

Publication history

  • Accepted July 26, 2021
  • First published August 25, 2021.
Online issue publication 
August 25, 2021

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