You are here

  • Home
  • Archive
  • Volume 9, Issue 8
  • Cystathionine β-synthase mediated PRRX2/IL-6/STAT3 inactivation suppresses Tregs infiltration and induces apoptosis to inhibit HCC carcinogenesis

Article info

Article menu
XML
Basic tumor immunology
Original research
Cystathionine β-synthase mediated PRRX2/IL-6/STAT3 inactivation suppresses Tregs infiltration and induces apoptosis to inhibit HCC carcinogenesis

Authors

  • Yu-Fu Zhou Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education & Research Unit of Liver cancer Recurrence and Metastasis, Chinese Academy of Medical Sciences, Shanghai, People's Republic of ChinaDepartment of Immunology and Pathogenic Biology, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China PubMed articlesGoogle scholar articles
  • Shu-Shu Song Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education & Research Unit of Liver cancer Recurrence and Metastasis, Chinese Academy of Medical Sciences, Shanghai, People's Republic of ChinaDepartment of Biochemistry and Molecular, School of Basic Medical Sciences, Fudan University, Shanghai, People's Republic of China PubMed articlesGoogle scholar articles
  • Meng-Xin Tian Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education & Research Unit of Liver cancer Recurrence and Metastasis, Chinese Academy of Medical Sciences, Shanghai, People's Republic of China PubMed articlesGoogle scholar articles
  • Zheng Tang Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education & Research Unit of Liver cancer Recurrence and Metastasis, Chinese Academy of Medical Sciences, Shanghai, People's Republic of China PubMed articlesGoogle scholar articles
  • Han Wang Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education & Research Unit of Liver cancer Recurrence and Metastasis, Chinese Academy of Medical Sciences, Shanghai, People's Republic of China PubMed articlesGoogle scholar articles
  • Yuan Fang Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education & Research Unit of Liver cancer Recurrence and Metastasis, Chinese Academy of Medical Sciences, Shanghai, People's Republic of China PubMed articlesGoogle scholar articles
  • Wei-Feng Qu Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education & Research Unit of Liver cancer Recurrence and Metastasis, Chinese Academy of Medical Sciences, Shanghai, People's Republic of China PubMed articlesGoogle scholar articles
  • Xi-Fei Jiang Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education & Research Unit of Liver cancer Recurrence and Metastasis, Chinese Academy of Medical Sciences, Shanghai, People's Republic of China PubMed articlesGoogle scholar articles
  • Chen-Yang Tao Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education & Research Unit of Liver cancer Recurrence and Metastasis, Chinese Academy of Medical Sciences, Shanghai, People's Republic of China PubMed articlesGoogle scholar articles
  • Run Huang Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education & Research Unit of Liver cancer Recurrence and Metastasis, Chinese Academy of Medical Sciences, Shanghai, People's Republic of China PubMed articlesGoogle scholar articles
  • Pei-Yun Zhou Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education & Research Unit of Liver cancer Recurrence and Metastasis, Chinese Academy of Medical Sciences, Shanghai, People's Republic of China PubMed articlesGoogle scholar articles
  • Shi-Guo Zhu Department of Immunology and Pathogenic Biology, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China PubMed articlesGoogle scholar articles
  • Jian Zhou Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education & Research Unit of Liver cancer Recurrence and Metastasis, Chinese Academy of Medical Sciences, Shanghai, People's Republic of ChinaInstitutes of Biomedical Sciences, Fudan University, Shanghai, People's Republic of China PubMed articlesGoogle scholar articles
  • Jia Fan Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education & Research Unit of Liver cancer Recurrence and Metastasis, Chinese Academy of Medical Sciences, Shanghai, People's Republic of ChinaInstitutes of Biomedical Sciences, Fudan University, Shanghai, People's Republic of China PubMed articlesGoogle scholar articles
  • Wei-Ren Liu Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education & Research Unit of Liver cancer Recurrence and Metastasis, Chinese Academy of Medical Sciences, Shanghai, People's Republic of China PubMed articlesGoogle scholar articles
  • Ying-Hong Shi Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University & Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education & Research Unit of Liver cancer Recurrence and Metastasis, Chinese Academy of Medical Sciences, Shanghai, People's Republic of China PubMed articlesGoogle scholar articles
  1. Correspondence to Professor Ying-Hong Shi; shi.yinghong{at}zs-hospital.sh.cn; Dr Wei-Ren Liu; liu.weiren{at}zs-hospital.sh.cn
View Full Text

Citation

Zhou Y, Song S, Tian M, et al
Cystathionine β-synthase mediated PRRX2/IL-6/STAT3 inactivation suppresses Tregs infiltration and induces apoptosis to inhibit HCC carcinogenesis
Journal for ImmunoTherapy of Cancer 2021;9:e003031. doi: 10.1136/jitc-2021-003031

Publication history

  • Accepted July 8, 2021
  • First published August 19, 2021.
Online issue publication 
November 02, 2022

  • Supplementary Data

    This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Copyright information

© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.