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Original research
Intratumoral injection of TLR9 agonist promotes an immunopermissive microenvironment transition and causes cooperative antitumor activity in combination with anti-PD1 in pancreatic cancer

Authors

  • Carmine Carbone Medical Oncology, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy PubMed articlesGoogle scholar articles
  • Geny Piro Medical Oncology, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy PubMed articlesGoogle scholar articles
  • Antonio Agostini Medical Oncology, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy PubMed articlesGoogle scholar articles
  • Pietro Delfino Department of Diagnostics and Public Health, University and Hospital Trust of Verona, Verona, ItalyARC-Net Research Centre, University and Hospital Trust of Verona, Verona, Italy PubMed articlesGoogle scholar articles
  • Francesco De Sanctis Department of Medicine, Section of Immunology, University of Verona, Verona, Italy PubMed articlesGoogle scholar articles
  • Vincenzo Nasca Medical Oncology, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Italy PubMed articlesGoogle scholar articles
  • Francesco Spallotta Institute for Systems Analysis and Computer Science “A. Ruberti”, National Research Council (IASI – CNR), Rome, Italy PubMed articlesGoogle scholar articles
  • Claudio Sette Department of Neuroscience, Catholic University of the Sacred Heart, Milano, Italy PubMed articlesGoogle scholar articles
  • Maurizio Martini Division of Anatomic Pathology and Histology, Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, Rome, Italy PubMed articlesGoogle scholar articles
  • Stefano Ugel Department of Medicine, Section of Immunology, University of Verona, Verona, Italy PubMed articlesGoogle scholar articles
  • Vincenzo Corbo Department of Diagnostics and Public Health, University and Hospital Trust of Verona, Verona, ItalyARC-Net Research Centre, University and Hospital Trust of Verona, Verona, Italy PubMed articlesGoogle scholar articles
  • Paola Cappello Department of Molecular Biotechnology and Health Sciences, University of Turin, Turin, Italy PubMed articlesGoogle scholar articles
  • Emilio Bria Medical Oncology, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, ItalyMedical Oncology, Department of Translational Medicine, Catholic University of the Sacred Heart, Rome, Italy PubMed articlesGoogle scholar articles
  • Aldo Scarpa Department of Diagnostics and Public Health, University and Hospital Trust of Verona, Verona, ItalyARC-Net Research Centre, University and Hospital Trust of Verona, Verona, Italy PubMed articlesGoogle scholar articles
  • Giampaolo Tortora Medical Oncology, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, ItalyMedical Oncology, Department of Translational Medicine, Catholic University of the Sacred Heart, Rome, Italy PubMed articlesGoogle scholar articles
  1. Correspondence to Professor Giampaolo Tortora; giampaolo.tortora{at}policlinicogemelli.it
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Citation

Carbone C, Piro G, Agostini A, et al
Intratumoral injection of TLR9 agonist promotes an immunopermissive microenvironment transition and causes cooperative antitumor activity in combination with anti-PD1 in pancreatic cancer

Publication history

  • Accepted August 15, 2021
  • First published September 2, 2021.
Online issue publication 
September 02, 2021

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