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Poster Presentations
P02 Tumor microenvironment and microbiome in Immunotherapy
P02.04 Tissue-infiltrating Th9 cells in human endometrial cancer
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  1. H Tong1,
  2. H Feng2,3,4 and
  3. X Wan1
  1. 1Shanghai First Maternity and Infant Hospital, Shanghai, China
  2. 2Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
  3. 3Shanghai Institute of Transplantation, Shanghai, China
  4. 4Alumni Network of Ludwig-Maximilians University of Munich, Shanghai, China

Abstract

Background Endometrial cancer (EC) is a hormone-related carcinoma with increased morbidity among female patients of all backgrounds. The immune microenvironment of EC is uncertain.

Materials and Methods 102 patients were recruited in the present study. 90 postoperative specimens from the patients were analyzed by immunohistochemistry. The leukocyte landscape of endometrial cancer was mapped using high-dimensional single-cell profiling (CyTOF) for 12 patients.

Results NK cells, MDMs, and neutrophils were enriched in adjacent normal tissue. CCR5+CD38+ PD1+Th9 cells were enriched in the invasive margin. Additionally, PD1+ESRneg T cells and Siglec1+CCR5+CD40+ESRhi macrophage were infiltrated in the tumors.

Abstract P02.04 Figure 1
Abstract P02.04 Figure 1

Conclusions Immunological landscape of EC might shed light on new immunotherapuetic approach.

Disclosure Information H. Tong: None. H. Feng: None. X. Wan: None.

https://doi.org/10.1136/jitc-2021-ITOC8.16

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