PT - JOURNAL ARTICLE AU - Lorenzo Galluzzi AU - Ilio Vitale AU - Sarah Warren AU - Sandy Adjemian AU - Patrizia Agostinis AU - Aitziber Buqué Martinez AU - Timothy A Chan AU - George Coukos AU - Sandra Demaria AU - Eric Deutsch AU - Dobrin Draganov AU - Richard L Edelson AU - Silvia C Formenti AU - Jitka Fucikova AU - Lucia Gabriele AU - Udo S Gaipl AU - Sofia R Gameiro AU - Abhishek D Garg AU - Encouse Golden AU - Jian Han AU - Kevin J Harrington AU - Akseli Hemminki AU - James W Hodge AU - Dewan Md Sakib Hossain AU - Tim Illidge AU - Michael Karin AU - Howard L Kaufman AU - Oliver Kepp AU - Guido Kroemer AU - Juan Jose Lasarte AU - Sherene Loi AU - Michael T Lotze AU - Gwenola Manic AU - Taha Merghoub AU - Alan A Melcher AU - Karen L Mossman AU - Felipe Prosper AU - Øystein Rekdal AU - Maria Rescigno AU - Chiara Riganti AU - Antonella Sistigu AU - Mark J Smyth AU - Radek Spisek AU - John Stagg AU - Bryan E Strauss AU - Daolin Tang AU - Kazuki Tatsuno AU - Stefaan W van Gool AU - Peter Vandenabeele AU - Takahiro Yamazaki AU - Dmitriy Zamarin AU - Laurence Zitvogel AU - Alessandra Cesano AU - Francesco M Marincola TI - Consensus guidelines for the definition, detection and interpretation of immunogenic cell death AID - 10.1136/jitc-2019-000337 DP - 2020 Mar 01 TA - Journal for ImmunoTherapy of Cancer PG - e000337 VI - 8 IP - 1 4099 - http://jitc.bmj.com/content/8/1/e000337.short 4100 - http://jitc.bmj.com/content/8/1/e000337.full SO - J Immunother Cancer2020 Mar 01; 8 AB - Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation.