RT Journal Article SR Electronic T1 Consensus guidelines for the definition, detection and interpretation of immunogenic cell death JF Journal for ImmunoTherapy of Cancer JO J Immunother Cancer FD BMJ Publishing Group Ltd SP e000337 DO 10.1136/jitc-2019-000337 VO 8 IS 1 A1 Lorenzo Galluzzi A1 Ilio Vitale A1 Sarah Warren A1 Sandy Adjemian A1 Patrizia Agostinis A1 Aitziber Buqué Martinez A1 Timothy A Chan A1 George Coukos A1 Sandra Demaria A1 Eric Deutsch A1 Dobrin Draganov A1 Richard L Edelson A1 Silvia C Formenti A1 Jitka Fucikova A1 Lucia Gabriele A1 Udo S Gaipl A1 Sofia R Gameiro A1 Abhishek D Garg A1 Encouse Golden A1 Jian Han A1 Kevin J Harrington A1 Akseli Hemminki A1 James W Hodge A1 Dewan Md Sakib Hossain A1 Tim Illidge A1 Michael Karin A1 Howard L Kaufman A1 Oliver Kepp A1 Guido Kroemer A1 Juan Jose Lasarte A1 Sherene Loi A1 Michael T Lotze A1 Gwenola Manic A1 Taha Merghoub A1 Alan A Melcher A1 Karen L Mossman A1 Felipe Prosper A1 Øystein Rekdal A1 Maria Rescigno A1 Chiara Riganti A1 Antonella Sistigu A1 Mark J Smyth A1 Radek Spisek A1 John Stagg A1 Bryan E Strauss A1 Daolin Tang A1 Kazuki Tatsuno A1 Stefaan W van Gool A1 Peter Vandenabeele A1 Takahiro Yamazaki A1 Dmitriy Zamarin A1 Laurence Zitvogel A1 Alessandra Cesano A1 Francesco M Marincola YR 2020 UL http://jitc.bmj.com/content/8/1/e000337.abstract AB Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation.