RT Journal Article SR Electronic T1 The Great Debate at ‘Immunotherapy Bridge’, Naples, December 5, 2019 JF Journal for ImmunoTherapy of Cancer JO J Immunother Cancer FD BMJ Publishing Group Ltd SP e000921 DO 10.1136/jitc-2020-000921 VO 8 IS 2 A1 Ascierto, Paolo A A1 Bifulco, Carlo A1 Galon, Jerome A1 Garbe, Claus A1 Khleif, Samir N A1 McQuade, Jennifer A1 Odunsi, Kunle A1 Okada, Hideho A1 Paulos, Chrystal M A1 Quezada, Sergio A A1 Tawbi, Hussein A A1 Timmerman, John A1 Trinchieri, Giorgio A1 Butterfield, Lisa H A1 Puzanov, Igor YR 2020 UL http://jitc.bmj.com/content/8/2/e000921.abstract AB As part of the 2019 Immunotherapy Bridge congress (December 4–5, Naples, Italy), the Great Debate session featured counterpoint views from leading experts on six topical issues in immunotherapy today. These were the use of chimeric antigen receptor T cell therapy in solid tumors, whether the Immunoscore should be more widely used in clinical practice, whether antibody-dependent cellular cytotoxicity is important in the mode of action of anticytotoxic T-lymphocyte-associated protein 4 antibodies, whether the brain is immunologically unique or just another organ, the role of microbiome versus nutrition in affecting responses to immunotherapy, and whether chemotherapy is immunostimulatory or immunosuppressive. Discussion of these important topics are summarized in this report.