RT Journal Article
SR Electronic
T1 Interrogation of the cellular immunome of cancer patients with regard to the COVID-19 pandemic
JF Journal for ImmunoTherapy of Cancer
JO J Immunother Cancer
FD BMJ Publishing Group Ltd
SP e002087
DO 10.1136/jitc-2020-002087
VO 9
IS 3
A1 Renee N Donahue
A1 Jennifer L Marté
A1 Meghali Goswami
A1 Nicole J Toney
A1 Yo-Ting Tsai
A1 James L Gulley
A1 Jeffrey Schlom
YR 2021
UL http://jitc.bmj.com/content/9/3/e002087.abstract
AB While vaccines directed against the SARS-CoV-2 spike protein will have varying degrees of effectiveness in preventing SARS-CoV-2 infections, the severity of infection will be determined by multiple host factors including the ability of immune cells to lyse virus-infected cells. This review will discuss the complexity of both adaptive and innate immunomes and how a flow-based assay can detect up to 158 distinct cell subsets in the periphery. This assay has been employed to show the effect of age on differences in specific immune cell subsets, and the differences in the immunome between healthy donors and age-matched cancer patients. Also reviewed are the numerous soluble factors, in addition to cytokines, that may vary in the pathogenesis of SARS-CoV-2 infections and may also be employed to help define the effectiveness of a given vaccine or other antiviral agents. Various steroids have been employed in the management of autoimmune adverse events in cancer patients receiving immunotherapeutics and may be employed in the management of SARS-CoV-2 infections. The influence of steroids on multiple immune cells subsets will also be discussed.