RT Journal Article SR Electronic T1 Letter to the editor: radiomics analysis for predicting pembrolizumab response in patients with advanced rare cancers JF Journal for ImmunoTherapy of Cancer JO J Immunother Cancer FD BMJ Publishing Group Ltd SP e003044 DO 10.1136/jitc-2021-003044 VO 9 IS 7 A1 Mateus Trinconi Cunha A1 Vinicius Jardim Carvalho A1 Rafael Maffei Loureiro A1 Carlos Eduardo Brantis-de-Carvalho A1 Murilo Bicudo Cintra A1 Gilberto de Castro Junior YR 2021 UL http://jitc.bmj.com/content/9/7/e003044.abstract AB A commentary on the original research article: ‘Radiomics analysis for predicting pembrolizumab response in patients with advanced rare cancers’. Of note, the predictor selection process, the cross-validation method, along with the lack of final testing of the developed model with a separated data set may mask overfitting, overestimating performance metrics.