RT Journal Article SR Electronic T1 Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of hepatocellular carcinoma JF Journal for ImmunoTherapy of Cancer JO J Immunother Cancer FD BMJ Publishing Group Ltd SP e002794 DO 10.1136/jitc-2021-002794 VO 9 IS 9 A1 Tim F Greten A1 Ghassan K Abou-Alfa A1 Ann-Lii Cheng A1 Austin G Duffy A1 Anthony B. El-Khoueiry A1 Richard S Finn A1 Peter R Galle A1 Lipika Goyal A1 Aiwu Ruth He A1 Ahmed O Kaseb A1 Robin Kate Kelley A1 Riccardo Lencioni A1 Amaia Lujambio A1 Donna Mabry Hrones A1 David J Pinato A1 Bruno Sangro A1 Roberto I Troisi A1 Andrea Wilson Woods A1 Thomas Yau A1 Andrew X Zhu A1 Ignacio Melero YR 2021 UL http://jitc.bmj.com/content/9/9/e002794.abstract AB Patients with advanced hepatocellular carcinoma (HCC) have historically had few options and faced extremely poor prognoses if their disease progressed after standard-of-care tyrosine kinase inhibitors (TKIs). Recently, the standard of care for HCC has been transformed as a combination of the immune checkpoint inhibitor (ICI) atezolizumab plus the anti-vascular endothelial growth factor (VEGF) antibody bevacizumab was shown to offer improved overall survival in the first-line setting. Immunotherapy has demonstrated safety and efficacy in later lines of therapy as well, and ongoing trials are investigating novel combinations of ICIs and TKIs, in addition to interventions earlier in the course of disease or in combination with liver-directed therapies. Because HCC usually develops against a background of cirrhosis, immunotherapy for liver tumors is complex and oncologists need to account for both immunological and hepatological considerations when developing a treatment plan for their patients. To provide guidance to the oncology community on important concerns for the immunotherapeutic care of HCC, the Society for Immunotherapy of Cancer (SITC) convened a multidisciplinary panel of experts to develop a clinical practice guideline (CPG). The expert panel drew on the published literature as well as their clinical experience to develop recommendations for healthcare professionals on these important aspects of immunotherapeutic treatment for HCC, including diagnosis and staging, treatment planning, immune-related adverse events (irAEs), and patient quality of life (QOL) considerations. The evidence- and consensus-based recommendations in this CPG are intended to give guidance to cancer care providers treating patients with HCC.