RT Journal Article SR Electronic T1 Tissue-resident memory T cells in gastrointestinal cancer immunology and immunotherapy: ready for prime time? JF Journal for ImmunoTherapy of Cancer JO J Immunother Cancer FD BMJ Publishing Group Ltd SP e003472 DO 10.1136/jitc-2021-003472 VO 10 IS 4 A1 Syrine Abdeljaoued A1 Sara Arfa A1 Marie Kroemer A1 Myriam Ben Khelil A1 Angélique Vienot A1 Bruno Heyd A1 Romain Loyon A1 Alexandre Doussot A1 Christophe Borg YR 2022 UL http://jitc.bmj.com/content/10/4/e003472.abstract AB Tissue-resident memory T (TRM) cells have emerged as immune sentinels that patrol the tissue microenvironment and orchestrate localized antitumor immunity in various solid cancers. Recent studies have revealed that TRM cells are key players in cancer immunosurveillance, and their involvement has been linked to favorable responses to immunotherapy as well as general better clinical outcome in cancer patients. In this review, we provide an overview of the major advances and recent findings regarding TRM cells phenotype, transcriptional and epigenetic regulation in cancer with a special focus on gastrointestinal tumors. Finally, we highlight the exciting clinical implication of TRM cells in these types of tumors.