PT  - JOURNAL ARTICLE
AU  - Sun, Roger
AU  - Henry, Théophraste
AU  - Laville, Adrien
AU  - Carré, Alexandre
AU  - Hamaoui, Anthony
AU  - Bockel, Sophie
AU  - Chaffai, Ines
AU  - Levy, Antonin
AU  - Chargari, Cyrus
AU  - Robert, Charlotte
AU  - Deutsch, Eric
TI  - Imaging approaches and radiomics: toward a new era of ultraprecision radioimmunotherapy?
AID  - 10.1136/jitc-2022-004848
DP  - 2022 Jul 01
TA  - Journal for ImmunoTherapy of Cancer
PG  - e004848
VI  - 10
IP  - 7
4099  - http://jitc.bmj.com/content/10/7/e004848.short
4100  - http://jitc.bmj.com/content/10/7/e004848.full
SO  - J Immunother Cancer2022 Jul 01; 10
AB  - Strong rationale and a growing number of preclinical and clinical studies support combining radiotherapy and immunotherapy to improve patient outcomes. However, several critical questions remain, such as the identification of patients who will benefit from immunotherapy and the identification of the best modalities of treatment to optimize patient response. Imaging biomarkers and radiomics have recently emerged as promising tools for the non-invasive assessment of the whole disease of the patient, allowing comprehensive analysis of the tumor microenvironment, the spatial heterogeneity of the disease and its temporal changes. This review presents the potential applications of medical imaging and the challenges to address, in order to help clinicians choose the optimal modalities of both radiotherapy and immunotherapy, to predict patient’s outcomes and to assess response to these promising combinations.