PT - JOURNAL ARTICLE AU - Roger Sun AU - Théophraste Henry AU - Adrien Laville AU - Alexandre Carré AU - Anthony Hamaoui AU - Sophie Bockel AU - Ines Chaffai AU - Antonin Levy AU - Cyrus Chargari AU - Charlotte Robert AU - Eric Deutsch TI - Imaging approaches and radiomics: toward a new era of ultraprecision radioimmunotherapy? AID - 10.1136/jitc-2022-004848 DP - 2022 Jul 01 TA - Journal for ImmunoTherapy of Cancer PG - e004848 VI - 10 IP - 7 4099 - http://jitc.bmj.com/content/10/7/e004848.short 4100 - http://jitc.bmj.com/content/10/7/e004848.full SO - J Immunother Cancer2022 Jul 01; 10 AB - Strong rationale and a growing number of preclinical and clinical studies support combining radiotherapy and immunotherapy to improve patient outcomes. However, several critical questions remain, such as the identification of patients who will benefit from immunotherapy and the identification of the best modalities of treatment to optimize patient response. Imaging biomarkers and radiomics have recently emerged as promising tools for the non-invasive assessment of the whole disease of the patient, allowing comprehensive analysis of the tumor microenvironment, the spatial heterogeneity of the disease and its temporal changes. This review presents the potential applications of medical imaging and the challenges to address, in order to help clinicians choose the optimal modalities of both radiotherapy and immunotherapy, to predict patient’s outcomes and to assess response to these promising combinations.