TY - JOUR T1 - Imaging approaches and radiomics: toward a new era of ultraprecision radioimmunotherapy? JF - Journal for ImmunoTherapy of Cancer JO - J Immunother Cancer DO - 10.1136/jitc-2022-004848 VL - 10 IS - 7 SP - e004848 AU - Roger Sun AU - Théophraste Henry AU - Adrien Laville AU - Alexandre Carré AU - Anthony Hamaoui AU - Sophie Bockel AU - Ines Chaffai AU - Antonin Levy AU - Cyrus Chargari AU - Charlotte Robert AU - Eric Deutsch Y1 - 2022/07/01 UR - http://jitc.bmj.com/content/10/7/e004848.abstract N2 - Strong rationale and a growing number of preclinical and clinical studies support combining radiotherapy and immunotherapy to improve patient outcomes. However, several critical questions remain, such as the identification of patients who will benefit from immunotherapy and the identification of the best modalities of treatment to optimize patient response. Imaging biomarkers and radiomics have recently emerged as promising tools for the non-invasive assessment of the whole disease of the patient, allowing comprehensive analysis of the tumor microenvironment, the spatial heterogeneity of the disease and its temporal changes. This review presents the potential applications of medical imaging and the challenges to address, in order to help clinicians choose the optimal modalities of both radiotherapy and immunotherapy, to predict patient’s outcomes and to assess response to these promising combinations. ER -