RT Journal Article
SR Electronic
T1 Imaging approaches and radiomics: toward a new era of ultraprecision radioimmunotherapy?
JF Journal for ImmunoTherapy of Cancer
JO J Immunother Cancer
FD BMJ Publishing Group Ltd
SP e004848
DO 10.1136/jitc-2022-004848
VO 10
IS 7
A1 Roger Sun
A1 Théophraste Henry
A1 Adrien Laville
A1 Alexandre Carré
A1 Anthony Hamaoui
A1 Sophie Bockel
A1 Ines Chaffai
A1 Antonin Levy
A1 Cyrus Chargari
A1 Charlotte Robert
A1 Eric Deutsch
YR 2022
UL http://jitc.bmj.com/content/10/7/e004848.abstract
AB Strong rationale and a growing number of preclinical and clinical studies support combining radiotherapy and immunotherapy to improve patient outcomes. However, several critical questions remain, such as the identification of patients who will benefit from immunotherapy and the identification of the best modalities of treatment to optimize patient response. Imaging biomarkers and radiomics have recently emerged as promising tools for the non-invasive assessment of the whole disease of the patient, allowing comprehensive analysis of the tumor microenvironment, the spatial heterogeneity of the disease and its temporal changes. This review presents the potential applications of medical imaging and the challenges to address, in order to help clinicians choose the optimal modalities of both radiotherapy and immunotherapy, to predict patient’s outcomes and to assess response to these promising combinations.