RT Journal Article SR Electronic T1 Imaging approaches and radiomics: toward a new era of ultraprecision radioimmunotherapy? JF Journal for ImmunoTherapy of Cancer JO J Immunother Cancer FD BMJ Publishing Group Ltd SP e004848 DO 10.1136/jitc-2022-004848 VO 10 IS 7 A1 Sun, Roger A1 Henry, Théophraste A1 Laville, Adrien A1 Carré, Alexandre A1 Hamaoui, Anthony A1 Bockel, Sophie A1 Chaffai, Ines A1 Levy, Antonin A1 Chargari, Cyrus A1 Robert, Charlotte A1 Deutsch, Eric YR 2022 UL http://jitc.bmj.com/content/10/7/e004848.abstract AB Strong rationale and a growing number of preclinical and clinical studies support combining radiotherapy and immunotherapy to improve patient outcomes. However, several critical questions remain, such as the identification of patients who will benefit from immunotherapy and the identification of the best modalities of treatment to optimize patient response. Imaging biomarkers and radiomics have recently emerged as promising tools for the non-invasive assessment of the whole disease of the patient, allowing comprehensive analysis of the tumor microenvironment, the spatial heterogeneity of the disease and its temporal changes. This review presents the potential applications of medical imaging and the challenges to address, in order to help clinicians choose the optimal modalities of both radiotherapy and immunotherapy, to predict patient’s outcomes and to assess response to these promising combinations.