TY - JOUR T1 - New prognostic model in patients with advanced urothelial carcinoma treated with second-line immune checkpoint inhibitors JF - Journal for ImmunoTherapy of Cancer JO - J Immunother Cancer DO - 10.1136/jitc-2022-005977 VL - 11 IS - 1 SP - e005977 AU - Aristotelis Bamias AU - Axel Merseburger AU - Yohann Loriot AU - Nicholas James AU - Ernest Choy AU - Daniel Castellano AU - F Lopez-Rios AU - Fabio Calabrò AU - Mario Kramer AU - Guillermo de Velasco AU - Roubini Zakopoulou AU - Kimon Tzannis AU - Cora N Sternberg Y1 - 2023/01/01 UR - http://jitc.bmj.com/content/11/1/e005977.abstract N2 - Background Bellmunt Risk Score, based on Eastern Cooperative Oncology Group (ECOG) performance status (PS), hemoglobin levels and presence of liver metastases, is the most established prognostic algorithm for patients with advanced urothelial cancer (aUC) progressing after platinum-based chemotherapy. Nevertheless, existing algorithms may not be sufficient following the introduction of immunotherapy. Our aim was to develop an improved prognostic model in patients receiving second-line atezolizumab for aUC.Methods Patients with aUC progressing after cisplatin/carboplatin-based chemotherapy and enrolled in the prospective, single-arm, phase IIIb SAUL study were included in this analysis. Patients were treated with 3-weekly atezolizumab 1200 mg intravenously. The development and internal validation of a prognostic model for overall survival (OS) was performed using Cox regression analyses, bootstrapping methods and calibration.Results In 936 patients, ECOG PS, alkaline phosphatase, hemoglobin, neutrophil-to-lymphocyte ratio, liver metastases, bone metastases and time from last chemotherapy were identified as independent prognostic factors. In a 4-tier model, median OS for patients with 0–1, 2, 3–4 and 5–7 risk factors was 18.6, 10.4, 4.8 and 2.1 months, respectively. Compared with Bellmunt Risk Score, this model provided enhanced prognostic separation, with a c-index of 0.725 vs 0.685 and increment in c-statistic of 0.04 (p<0.001). Inclusion of PD-L1 expression did not improve the model.Conclusions We developed and internally validated a prognostic model for patients with aUC receiving postplatinum immunotherapy. This model represents an improvement over the Bellmunt algorithm and could aid selection of patients with aUC for second-line immunotherapy.Trial registration number NCT02928406.Data are available upon reasonable request. The data are available from the corresponding author upon reasonable request. ER -