PT  - JOURNAL ARTICLE
AU  - Medina, Jamie E
AU  - Dracopoli, Nicholas C
AU  - Bach, Peter B
AU  - Lau, Anna
AU  - Scharpf, Robert B
AU  - Meijer, Gerrit A
AU  - Andersen, Claus Lindbjerg
AU  - Velculescu, Victor E
TI  - Cell-free DNA approaches for cancer early detection and interception
AID  - 10.1136/jitc-2022-006013
DP  - 2023 Sep 01
TA  - Journal for ImmunoTherapy of Cancer
PG  - e006013
VI  - 11
IP  - 9
4099  - http://jitc.bmj.com/content/11/9/e006013.short
4100  - http://jitc.bmj.com/content/11/9/e006013.full
SO  - J Immunother Cancer2023 Sep 01; 11
AB  - Rapid advancements in the area of early cancer detection have brought us closer to achieving the goals of finding cancer early enough to treat or cure it, while avoiding harms of overdiagnosis. We evaluate progress in the development of early cancer detection tests in the context of the current principles for cancer screening. We review cell-free DNA (cfDNA)-based approaches using mutations, methylation, or fragmentomes for early cancer detection. Lastly, we discuss the challenges in demonstrating clinical utility of these tests before integration into routine clinical care.