RT Journal Article
SR Electronic
T1 Anti-PD-1 Vasculitis of the central nervous system or radionecrosis?
JF Journal for ImmunoTherapy of Cancer
JO J Immunother Cancer
FD BMJ Publishing Group Ltd
SP 96
DO 10.1186/s40425-017-0304-8
VO 5
IS 1
A1 Sun, Roger
A1 Danlos, Francois-Xavier
A1 Ammari, Samy
A1 Louvel, Guillaume
A1 Dhermain, Frédéric
A1 Champiat, Stéphane
A1 Lambotte, Olivier
A1 Deutsch, Eric
YR 2017
UL http://jitc.bmj.com/content/5/1/96.abstract
AB Commentary on « Cerebral vasculitis mimicking intracranial metastatic progression of lung cancer during PD-1 blockade » by Läubli H et al., J Immunother Cancer. 2017;5:46.The authors diagnosed a cerebral tumor-like lymphocytic vasculitis associated with anti-endothelial cell auto-antibodies secondary to anti-PD-1 therapy, treated by surgical resection and corticosteroids. We thought that this diagnosis should be discussed for at least two reasons. First, etiological explorations were not sufficient. Second, the diagnostic of radionecrosis should also be discussed.Abbreviations:ACNSAngiitis of the Central Nervous SystemANCAAnti neutrophil cytoplasmic antibodyMRIMagnetic Resonance ImagingPD-1Programmed cell death 1rCBVRelative cerebral blood volume