RT Journal Article
SR Electronic
T1 Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of bladder carcinoma
JF Journal for ImmunoTherapy of Cancer
JO J Immunother Cancer
FD BMJ Publishing Group Ltd
SP 68
DO 10.1186/s40425-017-0271-0
VO 5
IS 1
A1 Ashish M. Kamat
A1 Joaquim Bellmunt
A1 Matthew D. Galsky
A1 Badrinath R. Konety
A1 Donald L. Lamm
A1 David Langham
A1 Cheryl T. Lee
A1 Matthew I. Milowsky
A1 Michael A. O’Donnell
A1 Peter H. O’Donnell
A1 Daniel P. Petrylak
A1 Padmanee Sharma
A1 Eila C. Skinner
A1 Guru Sonpavde
A1 John A. Taylor III
A1 Prasanth Abraham
A1 Jonathan E. Rosenberg
YR 2017
UL http://jitc.bmj.com/content/5/1/68.abstract
AB The standard of care for most patients with non-muscle-invasive bladder cancer (NMIBC) is immunotherapy with intravesical Bacillus Calmette-Guérin (BCG), which activates the immune system to recognize and destroy malignant cells and has demonstrated durable clinical benefit. Urologic best-practice guidelines and consensus reports have been developed and strengthened based on data on the timing, dose, and duration of therapy from randomized clinical trials, as well as by critical evaluation of criteria for progression. However, these reports have not penetrated the community, and many patients do not receive appropriate therapy. Additionally, several immune checkpoint inhibitors have recently been approved for treatment of metastatic disease. The approval of immune checkpoint blockade for patients with platinum-resistant or -ineligible metastatic bladder cancer has led to considerations of expanded use for both advanced and, potentially, localized disease. To address these issues and others surrounding the appropriate use of immunotherapy for the treatment of bladder cancer, the Society for Immunotherapy of Cancer (SITC) convened a Task Force of experts, including physicians, patient advocates, and nurses, to address issues related to patient selection, toxicity management, clinical endpoints, as well as the combination and sequencing of therapies. Following the standard approach established by the Society for other cancers, a systematic literature review and analysis of data, combined with consensus voting was used to generate guidelines. Here, we provide a consensus statement for the use of immunotherapy in patients with bladder cancer, with plans to update these recommendations as the field progresses.Abbreviations:AUAAmerican Urologic AssociationBCGBacillus Calmette-GuérindMMRmismatch repair-deficientEAUEuropean Association of UrologyFDAU.S. Food and Drug AdministrationIBCGInternational Bladder Cancer GroupICUDInternational Consultation on Urological DiseasesMSI-HMicrosatellite instability-highNAMNational Academy of MedicineNCCNNational Comprehensive Cancer NetworkNMIBCnon-muscle invasive bladder cancerSITCSociety for Immunotherapy of Cancer