RT Journal Article
SR Electronic
T1 Tissue-resident lymphocytes: sentinel of the transformed tissue
JF Journal for ImmunoTherapy of Cancer
JO J Immunother Cancer
FD BMJ Publishing Group Ltd
SP 41
DO 10.1186/s40425-017-0244-3
VO 5
IS 1
A1 Saïda Dadi
A1 Ming O. Li
YR 2017
UL http://jitc.bmj.com/content/5/1/41.abstract
AB Tumor cells can be detected and cleared by lymphocytes in a process termed cancer immunosurveillance. However, the contributing cell types had not been fully characterized. Using oncogene-induced murine models of epithelial cancer, a recent study showed that cell transformation triggers expansion of tissue-resident lymphocytes derived from innate, T cell receptor (TCR) αβ and TCRγδ lineages. These type-1-like innate lymphoid cells (ILC1ls) and type 1 innate-like T cells (ILTC1s) share a gene expression program distinct from those of conventional lymphocytes, and exhibit cytolytic activities against tumor cells. Further deciphering such a tumor-elicited immunosurveillance mechanism may 1 day be harnessed for novel cancer immunotherapy.Abbreviations:CHILPCommon helper-like innate lymphoid progenitorcNKConventional natural killer cellsIELsIntestinal epithelial lymphocytesILCInnate lymphoid cellILC1lsType-1-like innate lymphoid cellsILTC1sType 1 innate-like T cellsSGSalivary glandTCRT cell receptor