TY - JOUR T1 - Ipilimumab induced digital vasculitis JF - Journal for ImmunoTherapy of Cancer JO - J Immunother Cancer DO - 10.1186/s40425-018-0321-2 VL - 6 IS - 1 SP - 12 AU - Amrita Padda AU - Elena Schiopu AU - Justin Sovich AU - Vincent Ma AU - Ajjai Alva AU - Leslie Fecher Y1 - 2018/12/01 UR - http://jitc.bmj.com/content/6/1/12.abstract N2 - Background Immune check point inhibitors (ICIs) have emerged as a new therapeutic paradigm for a variety of malignancies including metastatic melanoma. As the use of ICIs expand, immune-mediated adverse events are becoming a common occurrence.Case presentation We describe the first reported patient with small vessel vasculitis, manifested by digital ischemia, following treatment with high dose Ipilimumab for resected stage IIIB/C melanoma. This patient received high dose steroids, five-day intravenous (IV) Epoprostenol protocol, botulinum toxin injections, and Rituximab 375 mg/m2 weekly for four cycles. With this treatment regimen, the digital ischemia did not progress proximally, but she did require multiple distal digit amputations about six months after the onset of her symptoms.Conclusions Prompt identification and management of immune related adverse events (IRAEs) are critical to optimal patient management. This patient’s vasculitis did not reverse, but was likely halted and stabilized with multiple immunosuppressive medications.Abbreviations:CTLA-4Cytotoxic T-lymphocyte antigen 4ICIImmune checkpoint inhibitorIRAEImmune related adverse eventIVIntravenous ER -