RT Journal Article
SR Electronic
T1 Complete response to ipilimumab and nivolumab therapy in a patient with extensive extrapulmonary high-grade small cell carcinoma of the pancreas and HIV infection
JF Journal for ImmunoTherapy of Cancer
JO J Immunother Cancer
FD BMJ Publishing Group Ltd
SP 66
DO 10.1186/s40425-018-0379-x
VO 6
IS 1
A1 Husnain, Muhammad
A1 Park, Wungki
A1 Ramos, Juan Carlos
A1 Johnson, Thomas E.
A1 Chan, Joseph
A1 Dasari, Arvind
A1 Mudad, Raja
A1 Hosein, Peter J.
YR 2018
UL http://jitc.bmj.com/content/6/1/66.abstract
AB Background Immune checkpoint inhibitors (CPIs) have shown promising results in many solid tumors. There are limited data on the safety and efficacy of these drugs in HIV infected patients as they have traditionally been excluded from CPIs clinical trials.Case presentation We present a case of an HIV-positive patient with extensive extrapulmonary high-grade small cell carcinoma who was treated with dual CPIs (nivolumab and ipilimumab) with a complete response to therapy and with a manageable safety profile. We performed a comprehensive literature review identifying 62 total HIV positive cases treated with CPIs showing this to be a potentially safe option in HIV-positive patients.Conclusion HIV infection is not an absolute contraindication to CPI therapy. Our case and others provide justification for ongoing trials of CPI therapy in patients with HIV infection, a group that has traditionally been excluded from clinical trials.