Interaction analyses for double-inhibitory KIR and KIR ligand genotypes with TTRF
| TTRF | |||||
|---|---|---|---|---|---|
| Line | Treatment | Genotype Group | Number of Events/n | 4 yr Fail Rate (95% CI)a % | Interaction p-value |
| 1 | Maintenance | KIR2DL1+/C2+ and KIR3DL1+/Bw4+ | 17/44 | 37 (24–54) | 0.694 |
| 2 | Maintenance | not KIR2DL1+/C2+ and KIR3DL1+/Bw4+ | 11/36 | 34 (19–55) | |
| 3 | Non-Maintenance | KIR2DL1+/C2+ and KIR3DL1+/Bw4+ | 10/32 | 33 (18–54) | |
| 4 | Non-Maintenance | not KIR2DL1+/C2+ and KIR3DL1+/Bw4+ | 14/47 | 31 (19–48) | |
| 5 | Maintenance | Group 1: KIR2DL2+/C1+ and KIR3DL1+/Bw4+ | 9/22 | 45 (24–72) | 0.068 |
| 6 | Maintenance | Group 2:notKIR2DL2+/C1+ and KIR3DL1+/Bw4+ | 19/58 | 32 (21–47) | |
| 7 | Non-Maintenance | Group 1: KIR2DL2+/C1+ and KIR3DL1+/Bw4+ | 4/23 | 17 (6–44) | |
| 8 | Non-Maintenance | Group 2:notKIR2DL2+/C1+ and KIR3DL1+/Bw4+ | 20/56 | 38 (26–54) | |
| 9 | Maintenance | KIR2DL3+/C1+ and KIR3DL1+/Bw4+ | 12/35 | 38 (26–54) | 0.447 |
| 10 | Maintenance | not KIR2DL3+/C1+ and KIR3DL1+/Bw4+ | 16/45 | 34 (21–51) | |
| 11 | Non-Maintenance | KIR2DL3+/C1+ and KIR3DL1+/Bw4+ | 10/37 | 25 (13–44) | |
| 12 | Non-Maintenance | notT KIR2DL3+/C1+ and KIR3DL1+/Bw4+ | 14/42 | 38 (24–57) | |
a95% Confidence interval; lines 5-8 (bolded text) had a p-value <0.100 and were analyzed further for associations with outcome