Practical Advice for Clinical Management
| - Consult dermatology and biopsy right away, photographs recommended to help document rash. | |
| - Consider obtaining CRP as surrogate for IL-6 as patients may present with SIRS. | |
| - Consider re-initiation of therapy after rash (at lower dose, with steroid overlap), particularly if no signs of SJS, biopsy appears benign relative to clinical rash, and patient was having a good response to the therapy or does not have alternate therapy options. | |
| - Consider avoidance of other stimulating medications or known activating medications such as amoxicillin, amoxicillin-clavulanic acid, allopurinol |