Cox proportional-hazards regression: univariate and multivariate analyses of Progression Free Survival

Progression Free Survival
Univariate AnalysisMultivariate Analysis
VARIABLE (Comparator)HR (95% CI); p - valueHR (95% CI); p - value
BMI≥ 25 vs < 250.46 (0.39–0.54); p < 0.00010.71 (0.56–0.90); p < 0.0001
Weighta0.97 (0.96–0.98); p < 0.00010.99 (0.98–1.01); p = 0.1580
irAEs of any gradeYes vs No0.48 (0.41–0.57); p < 0.00010.67 (0.54–0.83); p = 0.0002
Primary Tumor (NSCLC)
 Melanoma0.52 (0.42–0.66); p < 0.00010.67 (0.53–0.85); p = 0.0008
 Kidney0.72 (0.58–0.91); p = 0.00620.67 (0.53–0.84); p = 0.0008
 Others1.08 (0.65–1.78); p = 0.75560.69 (0.41–1.15); p = 0.1533
Sex Male vs Female1.20 (1.01–1.42); p = 0.03141.03 (0.86–1.22); p = 0.7252
Age Elderly vs Non-elderly0.96 (0.82–1.12); p = 0.6394
Treatment line Non-first vs First1.62 (1.33–1.96); p < 0.00011.61 (1.32–1.93); p < 0.0001
N° of metastatic sites > 2 vs ≤ 21.46 (1.27–1.68); p < 0.00011.42 (1.21–1.67); p < 0.0001
ECOG PS ≥2 vs 0–12.60 (2.13–3.17); p < 0.00012.06 (1.67–2.52); p < 0.0001

aWeight was used as a continuous variable