CIK cells therapy-related adverse events according to category and grade
| Category | Patients no.(%) | Time to Onset(hours), Median (range) | Time of duration(hour), Median (range) | |||
|---|---|---|---|---|---|---|
| Total | Grade 1–2 | Grade 3–4 | treatments | |||
| Any | 12(8.0) | 11(7.3) | 1(0.7) | 2(1.3) | 4.5(0.5–30.0) | 12(0.5–36.0) |
| Fever | 4(2.7) | 3(2.0) | 1(0.7) | 1(0.7) | 3.75(2.5–6.0) | 6.75(2.0–12.0) |
| Chill | 4(2.7) | 4(2.7) | NA | NA | 2.0(1.5–4.5) | 1.25(0.5–2.0) |
| Rash | NA | NA | NA | NA | ||
| Pruritus | NA | NA | NA | NA | ||
| Arthralgia/myalgia | 3(2.0) | 3(2.0) | NA | NA | 12.0(8.0–20.0) | 24.0(12.0–36.0) |
| Fatigue | 3(2.0) | 3(2.0) | NA | NA | 6.0(4.0–12.0) | 18.0(12.0–24.0) |
| Anorexia | 3(2.0) | 3(2.0) | NA | NA | 20.0(6.0–30.0) | 20.0(12.0–36.0) |
| Nausea/vomiting | 1(0.7) | 1(0.7) | NA | NA | 1.5(NA) | 12.0(NA) |
| Allergic reaction | NA | NA | NA | NA | ||
| Hypertension | 1(0.7) | 1(0.7) | NA | 1(0.7) | 0.5(NA) | 1.5(NA) |
| Pneumonitis | NA | NA | NA | NA | ||
| Hepatitis | NA | NA | NA | NA | ||
| Colitis | NA | NA | NA | NA | ||
Abbreviations: NA Not applicable