Cox proportional-hazards regression: univariate and multivariate analyses according to non-overweight (< 25), overweight (25-30) and obese (≥ 30) BMI levels
| Univariate Analysis | Multivariate Analysis | |
|---|---|---|
| VARIABLE(Comparator) | HR (95% CI); p - value | HR (95% CI); p - value |
| BMI(< 25) | Time to Treatment Failure | |
| 25–30≥ 30 | 0.49 (0.41–0.58); p < 0.00010.60 (0.47–0.77); p = 0.0001 | 0.67 (0.53–0.84); p = 0.00080.86 (0.61–1.24); p = 0.4414 |
| BMI(< 25) | Progression Free Survival | |
| 25–30≥ 30 | 0.46 (0.39–0.55); p < 0.00010.46 (0.35–0.61); p < 0.0001 | 0.71 (0.56–0.89); p = 0.00440.80 (0.55–1.17); p = 0.2669 |
| BMI(< 25) | Overall Survival | |
| 25–30≥ 30 | 0.33 (0.27–0.41); p < 0.00010.34 (0.25–0.48); p < 0.0001 | 0.49 (0.37–0.64); p < 0.00010.61 (0.39–0.94); p = 0.0258 |
The used covariates (not shown) were: weight (continuous), irAEs of any grade, primary tumors, sex, line of treatment, ECOG-PS, number of metastatic sites