Cox proportional-hazards regression: univariate and multivariate analyses according to normal weight (18.5-25), overweight (25-30) and obese (≥ 30) BMI levels
| Univariate Analysis | Multivariate Analysis | |
|---|---|---|
| VARIABLE(Comparator) | HR (95% CI); p - value | HR (95% CI); p - value |
| BMI(18.5–25) | Time to Treatment Failure | |
| 25–30≥ 30 | 0.51 (0.43–0.61); p < 0.00010.63 (0.49–0.81); p = 0.0003 | 0.65 (0.51–0.82); p = 0.00040.79 (0.55–1.15); p = 0.2300 |
| BMI(18.5–25) | Progression Free Survival | |
| 25–30≥ 30 | 0.49 (0.41–0.58); p < 0.00010.48 (0.37–0.64); p < 0.0001 | 0.68 (0.53–0.87); p = 0.00160.72 (0.49–1.06); p = 0.0991 |
| BMI(18.5–25) | Overall Survival | |
| 25–30≥ 30 | 0.35 (0.29–0.43); p < 0.00010.37 (0.27–0.51); p < 0.0001 | 0.46 (0.35–0.61); p < 0.00010.50 (0.32–0.79); p = 0.0029 |
The used covariates (not shown) were: weight (continuous), irAEs of any grade, primary tumors, sex, line of treatment, ECOG-PS, number of metastatic sites