Cox proportional-hazards regression: univariate and multivariate analyses according to normal weight (18.5-25), overweight (25-30) and obese (≥ 30) BMI levels

Univariate AnalysisMultivariate Analysis
VARIABLE(Comparator)HR (95% CI); p - valueHR (95% CI); p - value
BMI(18.5–25)Time to Treatment Failure
25–30≥ 300.51 (0.43–0.61); p < 0.00010.63 (0.49–0.81); p = 0.00030.65 (0.51–0.82); p = 0.00040.79 (0.55–1.15); p = 0.2300
BMI(18.5–25)Progression Free Survival
25–30≥ 300.49 (0.41–0.58); p < 0.00010.48 (0.37–0.64); p < 0.00010.68 (0.53–0.87); p = 0.00160.72 (0.49–1.06); p = 0.0991
BMI(18.5–25)Overall Survival
25–30≥ 300.35 (0.29–0.43); p < 0.00010.37 (0.27–0.51); p < 0.00010.46 (0.35–0.61); p < 0.00010.50 (0.32–0.79); p = 0.0029

The used covariates (not shown) were: weight (continuous), irAEs of any grade, primary tumors, sex, line of treatment, ECOG-PS, number of metastatic sites