Multiparametric Cox analysis of predictive signatures (test set)
| Significant fixed covariate | Significance [fixed covariate] | Added covariate | Significance [added covariate] | Significance [Cox Model] |
|---|---|---|---|---|
| None | N/A | None | N/A | – |
| LM | + | PD-L1 expression | – | – |
| None | N/A | CD8+ cell density | + | – |
| LM | + | PD-L1+ cell density | + | – |
| None | N/A | CD8xPD-L1 signature | +++ | ++ |
The parameters shown represent an analysis performed on the test set of durvalumab-treated patient tumor samples. Fixed covariates at baselines were histology, smoking status, age, gender, liver metastasis, tumor stage and line of therapy. - > 0.05; + ≤ 0.05; ++ ≤ 0.005; +++ ≤ 0.0005
Abbreviations: CD8 Cluster of differentiation 8, LM Liver metastasis, N/A Not applicable, PD-L1 Programmed cell death ligand-1