Multiparametric Cox analysis of predictive signatures (test set)

Significant fixed covariateSignificance [fixed covariate]Added covariateSignificance [added covariate]Significance [Cox Model]
LM+PD-L1 expression
NoneN/ACD8+ cell density+
LM+PD-L1+ cell density+
NoneN/ACD8xPD-L1 signature+++++

The parameters shown represent an analysis performed on the test set of durvalumab-treated patient tumor samples. Fixed covariates at baselines were histology, smoking status, age, gender, liver metastasis, tumor stage and line of therapy. - > 0.05; + ≤ 0.05; ++ ≤ 0.005; +++ ≤ 0.0005

Abbreviations: CD8 Cluster of differentiation 8, LM Liver metastasis, N/A Not applicable, PD-L1 Programmed cell death ligand-1