Pros and Cons of using each TAA in the development of CAR-T cells in prostate cancer

TAADescriptionProsCons
PSASerine protease1) Almost exclusively expressed by prostate epithelial cells2) Stimulates cytotoxic lymphocytes in vivo [45]It is a prostate-specific but not tumor-specific antigen
PAPTyrosine phosphatase protein1) Secreted by benign and malignant prostate cells2) Stimulates CTLs in vivo [45]1) More highly expressed in Gleason score 6 and 7 tumors than in higher Gleason score tumors.2) Expressed in the placenta, kidneys and testes, and also in gastric, breast and colon cancer
PSCASerine proteaseExpression increases with both high Gleason score and metastasisPSCA has also been found expressed in other cancer types
PSMATransmembrane proteinEnhances cytokine productionAlso expressed in low levels in salivary glands, brain and kidneys
EpCAMTransmembrane proteinShow significance as a biomarker for early cancer developmentNot a prostate cancer- specific antigen

Abbreviations: TAA tumor associated antigen, PSA prostate-specific antigen, PAP prostatic acid phosphatase, PSCA prostate stem cell antigen, PSMA prostate-specific membrane antigen, EpCAM epithelial cell adhesion molecule precursor