CAR-T cell therapy studies on prostate cancer

PublicationPublication yearCountryInstitutionSettingCell source and typeGenerationCostimulatory domain
Gade et al [72]2005USAMemorial Sloan-Kettering Cancer CenterPreclinical - mice modelAnti PSMA CAR-T cellsFirst generation
Maher et al [73]2002USAMemorial Sloan-Kettering Cancer CenterPreclinicalAnti PSMA CAR-T cellsSecond generationCD28
Zuccolotto et al [74]2014ItalyUniversity of PaduaPreclinical - mice modelAnti PSMA CAR-T cellsSecond generationCD28
Ma et al [75]2014USARoger Williams Med CenterPreclinical - mice modelAnti PSMA CAR-T cellsSecond generationCD28
Slovin et al [76]2017USAMemorial Sloan-Kettering Cancer CenterPhase I NCT01140373Autologous T Anti PSMA CAR-T cellsSecond generationCD28
Kloss et al [77]2019USAUniversity of PennsylvaniaPreclinical - mice modelAnti PSMA-TGFβ insensitive CAR-T cellSecond generation4-1BB
Zhang et al [78]2018UKOxford UniversityPreclinical - mice modelAnti PSMA-TGFβ insensitive CAR-T cellSecond generation4-1BB
Hassani et al [79]2019IranTehran Univ Med SciencePreclinical - mice modelVHH-CAR-T cell anti PSMASecond generationCD28
Priceman et al [80]2017USACity of Hope, DuartePreclinical - mice modelAnti PSCA CAR-T cellSecond generation4-1BB
Hillerdal et al [81]2014SwedenUppsala UniversityPreclinical - mice modelAnti PSCA CAR-T cellThird generationCD28, OX-40 CD3ζ
Kloss et al [82]2012USAMemorial Sloan-Kettering Cancer CenterPreclinical - mice modelAnti PSCA/Anti PSMA CAR-T cellThird generation4-1BB, CD28
Feldman et al [83]2017GermanyInstitute of radiopharmaceutical Cancer Research, DresdenPreclinical - mice modelAnti PSCA/Anti PSMA CAR-T cellSecond generationCD28
Deng et al [84]2015ChinaCancer Hospital & InstitutePreclinical - mice modelAnti EpCAM CAR-T cellSecond generationCD28
NCT038738052019USACity of Hope, DuartePhase IAnti PSCA CAR-T cellSecond generation4-1BB

Abbreviations: CAR chimeric antigen receptor, PSMA prostate-specific membrane antigen, TGFβ transforming growth factor β, PSCA prostate stem cell antigen, EpCAM epithelial cell adhesion molecules, VHH camelid nanobody