Clinical characteristics of donor and mutation load in the 5 PDOs

CRC-01CRC-03CRC-04CRC-05CRC-08
Age at biopsy (years)6061595251
Sexmalefemalefemalemalemale
StageIVIVIVIVIV
Prior chemotherapyYesYesYesYesNo
Non-silent mutation load2081068918078
APCp.Y935X, p.S1411 fsp.R876Xp.S1356Xp.Q1367Xp.Y1075fs
TP53p.G245Sp.T284 fsp.R210Xp.R205C
KRASp.G12CAmplificationp.A18Dp.G12Dp.G12D
TCF7L2p.F105 fs
SMAD4p.G365R