DFS | Univariate HR (95% CI)b | p | Multivariate HR (95% CI)b | p | OS | Univariate HR (95% CI)b | p | Multivariate HR (95% CI)b | p |
---|---|---|---|---|---|---|---|---|---|
FIGO stage [advanced/early] | 3.6 (2.2–5.8) | < 0.001 | 2.3 (1.3–4.2) | 0.004 | FIGO stage [advanced/early] | 2.6 (1.3–4.8) | 0.004 | 1.3 (0.6–2.7) | 0.53 |
Histology [serous/non-serousa] | 1.5 (1.1–2.2) | 0.01 | 1.1 (0.8–1.6) | 0.63 | Histology [serous/non-serousa] | 1.1 (0.7–1.7) | 0.74 | ||
Tumor grade [3/1–2] | 2.0 (1.1–3.4) | 0.015 | 1.6 (0.9–2.8) | 0.11 | Tumor grade [3/1–2] | 1.4 (0.7–2.9) | 0.39 | ||
Postoperative residual tumor [≥1 cm/< 1 cm] | 2.8 (2.1–3.9) | < 0.001 | 2.1 (1.4–2.9) | < 0.001 | Postoperative residual tumor [> 1 cm/< 1 cm] | 3.1 (2.0–5.0) | < 0.001 | 2.7 (1.6–4.7) | < 0.001 |
BTLA expression [detectable/non- detectable] | 2.0 (1.4–2.9) | < 0.001 | 1.7 (1.2–2.4) | 0.002 | BTLA expression [detectable/non- detectable] | 2.0 (1.2–3.5) | 0.009 | 1.8 (1.04–3.0) | 0.035 |
Abbreviations: EOC epithelial ovarian carcinoma; DFS disease-free survival; OS overall survival; HR Hazard ratio; CI confidence interval; FIGO International Federation of Gynecology and Obstetrics; BTLA B and T lymphocyte attenuator
aNon-serous includes mucinous, clear cell, endometrioid, and undifferentiated types
bCox regression model