Variables | Univariate analysis | Multivariate analysis | |||||
---|---|---|---|---|---|---|---|
A | B | C | |||||
P | HR (95%CI) | P | HR (95%CI) | P | HR (95%CI) | P | |
Liver cirrhosis (no vs. yes) | 0.030 | 0.816 (0.418–1.591) | 0.550 | 0.816 (0.418–1.591) | 0.550 | 0.871 (0.449–1.688) | 0.682 |
Serum ALT, U/L (≤ 40 vs. > 40) | 0.001 | 0.534 (0.335–0.848) | 0.008 | 0.534 (0.335–0.848) | 0.008 | 0.552 (0.346–0.879) | 0.012 |
γ-GT, U/L (> 75 vs. ≤ 75) | 0.023 | 1.295 (0.883–1.898) | 0.185 | 1.295 (0.883–1.898) | 0.185 | 1.257 (0.856–1.846) | 0.243 |
Tumor size (cm) (> 5 vs. ≤ 5) | < 0.0001 | 1.984 (1.461–2.696) | < 0.0001 | 1.984 (1.461–2.696) | < 0.0001 | 2.006 (1.474–2.729) | < 0.0001 |
Tumor number (multiple vs. single) | 0.001 | 1.451 (1.006–2.092) | 0.046 | 1.451 (1.006–2.092) | 0.046 | 1.432 (0.993–2.064) | 0.054 |
Vascular invasion (yes vs. no) | < 0.0001 | 1.701 (1.254–2.307) | 0.001 | 1.701 (1.254–2.307) | 0.001 | 1.695 (1.250–2.300) | 0.001 |
TNM stage (I vs. II-III) | < 0.0001 | 0.799 (0.388–1.647) | 0.543 | 0.799 (0.388–1.647) | 0.543 | 0.831 (0.404–1.710) | 0.615 |
CD8+PD1Int/ CD8+PD1+ (high vs. low) | 0.005 | 0.686 (0.497–0.947) | 0.022 | ||||
CD8+PD1Hi/ CD8+PD1+(high vs. low) | 0.005 | 1.458 (1.056–2.013) | 0.022 | ||||
CD8+TIM3+ PD1Hi/ CD8+PD1+ (high vs. low) | 0.002 | 1.476 (1.085–2.008) | 0.013 |
Abbreviations: ALT Alanine transaminase, γ-GT Gamma-Glutamyl-transpeptidase, TNM Tumor-nodes-metastases, HR Hazard ratio, CI Confidential interval. A:CD8+PD1Int/ CD8+PD1+; B:CD8+PD1Hi/ CD8+PD1+; C:CD8+TIM3+PD1Hi/ CD8+PD1+. Multivariate analysis was performed by the Cox multivariate proportional hazard regression model with stepwise manner