Parameter | Pediatric/young adult model | Adult model | ||||
---|---|---|---|---|---|---|
Estimate | %RSE | Shrinkage (%) | Estimate | %RSE | Shrinkage (%) | |
CL (L/day) | 0.217 | 5 | 0.200 | 2 | ||
V1 (L) | 3.01 | 4 | 3.28 | 2 | ||
V2 (L) | 1.36 | 11 | 3.63 | 4 | ||
Q (L/day) | 0.183 | 18 | 0.546 | 8 | ||
Weight on CL | 0.795 | 8 | 0.808 | 8 | ||
Albumin on CL | −1.18 | 20 | −1.12 | 10 | ||
Tumor burden on CL | 0.122 | 35 | 0.125 | 17 | ||
Positive ADA on CL | 1.23 | 8 | 1.16 | 25 | ||
Weight on V1 | 0.766 | 8 | 0.559 | 8 | ||
Albumin on V1 | −0.566 | 29 | −0.350 | 21 | ||
Sex (female) on V1 | NE | – | − 0.129 | 16 | ||
Sex (female) on V2 | NE | – | −0.272 | 16 | ||
Proportional residual variance | 0.051 | 32 | 12 | 0.043 | 7 | 9 |
Additive residual variance | 68.9 | 109 | 12 | 16.6 | 39 | 9 |
BSV for CL | 0.0458 | 33 | 21 | 0.0867 | 9 | 9 |
BSV for V1 | 0.0140 | 65 | 43 | 0.0328 | 18 | 17 |
BSV for V2 | 0.311 | 63 | 39 | 0.114 | 25 | 33 |
Correlation of BSVs for CL, V1 | 0.510 | – | 0.341 | |||
Correlation of BSVs for CL, V2 | NE | – | −0.236 | |||
Correlation of BSVs for V1, V2 | NE | – | 0.434 | |||
Objective function | 3637 | 40,748 |
Abbreviations: %RSE Percent relative standard error, ADA Anti-drug antibody, BSV Between-subject variability, CL Clearance, NE Not evaluated, Q Inter-compartmental clearance, V1 Volume of the central compartment, V2 Volume of the peripheral compartment