Predicted summary statistics (median [min–max]) of atezolizumab exposure metrics

Metric	Observation	Body weight dose (< 18 years)			Flat dose (≥ 18 years)
Metric	Observation	< 30 kgn = 23	30 to < 45 kgn = 21	≥ 45 kgn = 25	< 57 kgn = 6	57 to < 65 kgn = 6	≥ 65 kgn = 6
Cmax, μg/mL	Cycle 1	270 [182–349]	330 [232–375]	349 [281–407]	492 [303–541]	486 [419–549]	326 [243–390]
Cmax, μg/mL	Steady-state	400 [277–517]	463 [257–585]	460 [319–618]	664 [377–764]	651 [505–868]	404 [334–540]
Cmin, μg/mL	Cycle 1	55.6 [28.1–82.0]	65.0 [20.7–91.9]	65.5 [27.4–108]	97.3 [47.4–122]	98.8 [56.9–151]	57.6 [28.4–87.5]
Cmin, μg/mL	Steady-state	120 [77.0–181]	125 [25.4–246]	112 [37.9–211]	171 [74.1–225]	164 [86.2–319]	88.1 [32.4–149]
AUC, μg*day/mL	Cycle 1	2085 [1089–3053]	2757 [1471–3312]	2988 [1975–3954]	4268 [2396–4845]	4330 [3175–5448]	2733 [2306–3701]
AUC, μg*day/mL	Steady-state	4045 [2536–5695]	4781 [1730–7295]	4510 [2417–7126]	6692 [3365–8125]	6574 [4276–10,405]	3861 [2593–5774]
CL, mL/day/kg	–	3.72 [2.62–5.89]	3.20 [2.06–8.67]	3.15 [2.90–6.10]	3.62 [2.61–5.20]	2.90 [1.99–4.92]	3.25 [1.70–5.16]

Abbreviations: AUC Area under the curve, C _max Maximum concentration, C _min Minimum concentration, CL Clearance