Variables | OS | RFS | ||||||
---|---|---|---|---|---|---|---|---|
Univariate | Multivariate | Univariate | Multivariate | |||||
p | HR | 95% CI | p | p | HR | 95% CI | p | |
Gender (female/male) | 0.396 | 0.528 | ||||||
Age,y (> 50/≤50) | 0.711 | 0.346 | ||||||
HBsAg (present/absent) | 0.759 | 0.107 | ||||||
AFP, ng/ml (> 25/≤25) | < 0.0001 | 1.588 | 1.122–2.249 | 0.009 | 0.001 | 1.258 | 0.963–1.643 | 0.092 |
Tumor size, cm (> 5/≤5) | 0.011 | 0.905 | 0.645–1.271 | 0.565 | 0.040 | 0.928 | 0.706–1.219 | 0.590 |
Tumor multiplicity (multiple/solitary) | < 0.0001 | 1.468 | 1.006–2.142 | 0.046 | < 0.0001 | 1.518 | 1.094–2.107 | 0.012 |
Vascular invasion (present/absent) | < 0.0001 | 3.389 | 2.205–5.209 | < 0.0001 | < 0.0001 | 2.257 | 1.547–3.293 | < 0.0001 |
TNM stage (III + IV/I + II) | < 0.0001 | 1.632 | 1.086–2.453 | 0.018 | < 0.0001 | 1.294 | 0.914–1.831 | 0.146 |
Differentiation (III + IV/I + II) | 0.55 | 0.700 | ||||||
Combination of EZH2 and PD-L1 | 0.0004 | 1.228 | 1.050–1.436 | 0.010 | 0.0002 | 1.254 | 1.100–1.430 | 0.001 |
Variables associated with overall survival or relapse-free survival by univariate analysis were adopted as covariates in multivariate analysis and entered into the equation by the forward selection based on likelihood ratio test
Abbreviations: OS Overall survival, RFS Relapse-free survival, HR Hazard ratio, CI Confidence interval