Multivariate Cox regression analysis of clinical parameters and serum biomarkers
| Parameter | Category | HR (95% CI) | P-value |
|---|---|---|---|
| ECOG status | n.a. (ordinal) | 3.19 (1.36–7.47) | 0.007* |
| LDH | normal | 1 | 0.428 |
| elevated (>ULN) | 1.83 (0.41–8.08) | ||
| CRP | normal | 1 | 0.534 |
| elevated (>ULN) | 1.73 (0.31–9.74) | ||
| Bone metastasis | no | 1 | 0.331 |
| yes | 2.02 (0.49–8.27) |
Four parameters were included in the multivariate Cox regression analysis. Of these factors, ECOG status was significantly associated with overall survival in this model. Abbreviations: CI Confidence interval, n.a. not applicable, ULN Institutional upper limit of normal, LDH Lactate dehydrogenase, CRP C-reactive protein; *p<0.05.